头颈部鳞癌患者血清血管内皮生长因子和人表皮生长因子受体-2水平的检测及临床意义-论文.pdf

《头颈部鳞癌患者血清血管内皮生长因子和人表皮生长因子受体-2水平的检测及临床意义-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、山西医药杂志2014年5月第43卷第9期ShanxiMedJ，May2014，Vo1．43，No．9·997·头颈部鳞癌患者血清血管内皮生长因子和人表皮生长因子受体一2水平的检测及临床意义甘世新姚景春乔飞飞【摘要】目的探讨头颈部鳞癌患者血清血管内皮生长因子(VEGF)和人表皮生长因子受体一2(HER2)表达情况与临床病理参数的关系以及二者之间的相互关系。方法收集6O例头颈部鳞癌患者血清和3O名健康体检者血清，应用酶联免疫吸附试验(ELISA)定量检测血清VEGF和HER2表达水平变化。结果试验组血清中VEGF的表达水平显著高于对照组(P

2、R2的差异不明显(P>O．05)。血清VEGF在鳞癌中的表达率随着分化程度的递减而增加，且淋巴结转移组血清VEGF水平显著高于无淋巴结转移组(P<0．05)。但血清VEGF表达与年龄、性别、肿瘤浸润深度等临床病理参数差异无统计学意义(P>O．05)。HER2的表达在各病理参数间差异无统计学意义(P>o．05)。二者的表达无相关性(r一0．147，P>0．05)。结论VEGF在头颈部鳞癌的发生发展过程中发挥重要作用，其与疾病的侵袭和转移有关，是重要的预后不良因子。而HER2在头颈部鳞癌发生发展中作用尚不确定。【关键词】头颈部肿瘤；血管内皮生长因子类；受体，表皮生长因

3、子Theexpressionandsignificanceofsel'umVEGFandHER2inpatientswithheadandnecksquamouscellcarcinomaCanShixin，YaoJingchun，QiaoFeifei．DepartmentofHeadandNeckSurgery，ShanxiTumorHospital，Taiyuan030013，China[Abstract]ObjectiveToinvestigatetheexpressionofserumVEGFandHER2inpatientswithheadandneck

4、squamouscellcarcinoma，andtoanalyzethecorrelationbetweentheexpressionandclinicalpathologicalparametersandthecorrelationofthem．MethodsELISAwasusedtOdetecttheserum1evelofVEGFandHER2in60headandnecksquamouscellcarcinomapatientsand30healthycontro1．ResultsTheexpressionofserumVEGFintheexperim

5、entalgroupwassignificantlyhigherthanthatofcontrolgroup(PO．05)．TheserumlevelofVEGFinpatientswithheadandnecksquamouscellcar—cinomashowedgradualincreasewithhistologicalgradesadvancing，andtheexpressioninthelymp

6、hnodemetastasisgroupissignificantlyhigherthanthatofnolymphnodemetastasis(PO．05)．NocorrelationwasobtainedbetweenHER2andgender，age，thedepthofinvasionorlymphnodemetastasis(P>0．05)．Norelationshipwasfound

7、betweenHER2andVEGFeither(r一0．147，P>0．05)．ConclusionVEGFiscloselyrelatedtotheoccurrenceanddevelopmentofheadandnecksqua—mouscellcarcinoma，whichisassociatedwiththeinvasionandmetastasisofthedisease．Itistheimportantprognosisfac—tor．TheroleofHER2inthedevelopmentofheadandnecksquamouscellcarc

8、inoma