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时间:2020-05-22
《重度子痫前期患者血管内皮生长因子及其受体-1水平变化及意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华实用诊断与治疗杂志2014年7月第28卷第7期JournalofChinesePracticalDiagnosisandTherapy·683··论著·重度子痫前期患者血管内皮生长因子及其受体一1水平变化及意义李玉芳,彭丽平,曾艳花,罗艺,吴雪琴(深圳市龙岗中心医院妇产科,广东深圳518116)摘要:目的检测早发型和晚发型重度子痫前期患者血清和胎盘中血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)及血管内皮生长因子受体一1(solublevascularendothelialgrowt
2、hfactorreceptors-1,sFlt一1)水平,探讨其在重度子痫前期发病中的作用机制。方法2O例早发型重度子痫前期患者为早发重度组,2O例晚发型重度子痫前期患者为晚发重度组,2O例正常晚期妊娠者为正常妊娠组,采用ELIsA法检测3组血清VEGF及sFlt一1水平,同时应用免疫组织化学SP法检测胎盘组织中VEGF及sFlt一1的阳性表达率。结果血清VEGF水平及胎盘VEGF阳性表达率早发重度组((27.5±3.6)ng/L和15)、晚发重度组((36.2±3.2)ng/L和3O)均低于正常妊娠组((45.5±3.7)ng/L
3、和45)(P4、ngesandclinicalsignificanceofvascularendothelialgrowthfactorandsolublevascularendothelialgrowthfactorreceptor一1inseverepreeclampsiapatientsLIYu—fang,PENGLi—ping,ZENGYan—hua,LUOYi,WUXue—qin(DepartmentofObstetricsandGynecology,LonggangDistrictCentralHospitalofShenzhen,Sh5、enzhen518116,China)Abstract:0bjectiveToexplorethemechanismofvascularendothelialgrowthfactor(VEGF)andsolublevascularendothelialgrowthfactorreceptor-1(sFlt一1)inseverepreeclampsiabydetectingtheirlevelsinserumandplacentainpregnantwomenwithearly-andlate-onsetseverepreeclamp6、sia.MethodsThelevelsofserumVEGFandSFh一1weredetectedbyELISAtechniquein20patientswithearly—onsetseverepreeclampsia(early—onsetgroup),20withlate—onsetseverepreeclampsia(1ate—onsetgroup)and20normalpregnantwomen(controlgroup).TheexpressionsofVEGFandSFlt一1inplacentaweredetec7、tedbySPmethod.ResultsThelevelsandpositiveratesofVEGFinserumandplacentawerelowerinearly-onsetgroup((27.5±3.6)ng/L,15)thanthoseinlate—onsetgroup((36.2±3.2)ng/L,3O)(P8、Flt-1inserumandplacentawerehigherinearly-onsetgroup((42.2±3.2)ng/L,60)thanthoseinlate—onsetgroup((3O.2±2.5)ng/L,45)(P
4、ngesandclinicalsignificanceofvascularendothelialgrowthfactorandsolublevascularendothelialgrowthfactorreceptor一1inseverepreeclampsiapatientsLIYu—fang,PENGLi—ping,ZENGYan—hua,LUOYi,WUXue—qin(DepartmentofObstetricsandGynecology,LonggangDistrictCentralHospitalofShenzhen,Sh
5、enzhen518116,China)Abstract:0bjectiveToexplorethemechanismofvascularendothelialgrowthfactor(VEGF)andsolublevascularendothelialgrowthfactorreceptor-1(sFlt一1)inseverepreeclampsiabydetectingtheirlevelsinserumandplacentainpregnantwomenwithearly-andlate-onsetseverepreeclamp
6、sia.MethodsThelevelsofserumVEGFandSFh一1weredetectedbyELISAtechniquein20patientswithearly—onsetseverepreeclampsia(early—onsetgroup),20withlate—onsetseverepreeclampsia(1ate—onsetgroup)and20normalpregnantwomen(controlgroup).TheexpressionsofVEGFandSFlt一1inplacentaweredetec
7、tedbySPmethod.ResultsThelevelsandpositiveratesofVEGFinserumandplacentawerelowerinearly-onsetgroup((27.5±3.6)ng/L,15)thanthoseinlate—onsetgroup((36.2±3.2)ng/L,3O)(P8、Flt-1inserumandplacentawerehigherinearly-onsetgroup((42.2±3.2)ng/L,60)thanthoseinlate—onsetgroup((3O.2±2.5)ng/L,45)(P
8、Flt-1inserumandplacentawerehigherinearly-onsetgroup((42.2±3.2)ng/L,60)thanthoseinlate—onsetgroup((3O.2±2.5)ng/L,45)(P
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