子痫前期患者血清瘦素及可溶性瘦素受体水平变化及临床意义

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1、子痫前期患者血清瘦素及可溶性瘦素受体水平变化及临床意义作者：吴维光，于月成，朱淑平，曹秀琴【关键词】妊娠并发症；高血压；瘦素；可溶性瘦素受体【Abstract】AIM:Toinvestigatetherelationsbetweenpreeclampticpathogenesisandchangesofserumleptinandsolubleleptinreceptorinpreeclampsia,andtheirclinicalsignificance.METHODS:Theperipheralve

2、nousbloodsamplesof40preeclampsiaand43normalpregnantwomenwereobtainedbeforeand7dafteroperation.Thelevelofleptinwasvaluedbyimmunoradioassay,andthelevelofsolubleleptinreceptorwasmeasuredbyenzymelinkedimmunosorbentassay(ELISA).Thecorrelativeanalysisbetweenth

3、elevelsofserumleptinandsolubleleptinreceptorandthebloodpressurewasperformed.RESULTS:Thelevelofleptinbeforeoperationwashigherthanthatafteroperationinallthepregnantwomen;Thelevelofleptinbeforeoperationinpreeclampsiawashigherthanthatinnormalpregnancy,andthe

4、levelofsolubleleptinreceptorbeforeoperationinpreeclampsiawaslowerthanthatinnormalpregnancy;Theleptinbeforeoperationinpreeclampsiawas8negativelycorrelatedwiththesolubleleptinreceptor,andtherewerepositivecorrelationsbetweentheleptinbeforeoperationinpreecla

5、mpsiaandthediastolicpressureorsystolicpressure;Therewerenegativecorrelationsbetweenthesolubleleptinreceptorbeforeoperationinpreeclampsiaandthediastolicpressureorsystolicpressure.CONCLUSION:Thehighlevelofleptininpreeclampsiamaycomefromplacenta,anditmayber

6、elatedtothepreeclampticpathophysiology.Thelevelofleptinorsolubleleptinreceptorcanbeaclinicalmarkertoreflectthedegreeofpreeclampsia.【Keywords】pregnancycomplications;hypertension;leptin;solubleleptinreceptor【摘要】目的：探讨子痫前期血清瘦素及可溶性瘦素受体水平与子痫前期发病之间的关系及其临床意义.方法：

7、40例子痫前期孕妇及43例正常妊娠孕妇，取术前及术后7d外周静脉血，应用放射免疫法检测瘦素水平，应用ELISA法检测可溶性瘦素受体水平，并与子痫前期的血压值进行相关分析.结果：8子痫前期组和正常妊娠组术后瘦素水平均低于术前；子痫前期组术前瘦素水平高于正常妊娠组，可溶性瘦素受体水平低于正常妊娠组；子痫前期组术前瘦素水平与可溶性瘦素受体水平呈负相关，与收缩压和舒张压呈正相关；子痫前期组术前可溶性瘦素受体水平与收缩压和舒张压均呈负相关.结论：子痫前期升高的瘦素可能来源于胎盘，并可能参与子痫前期的病理生理过程.

8、血清中瘦素及可溶性瘦素受体水平可作为反映疾病程度的临床指标.【关键词】妊娠并发症；高血压；瘦素；可溶性瘦素受体0引言瘦素是肥胖（obese）基因的蛋白产物，主要是由脂肪细胞合成和分泌，参与机体的能量代谢.但近年来研究发现，瘦素与妊娠和生殖调节也存在密切关系［1-2］.我们观察了子痫前期患者血清瘦素及可溶性瘦素水平变化，以探讨血清瘦素及可溶性瘦素受体与子痫前期之间的关系及其临床意义.1对象和方法1.1对象200401/200511武警医学院附