子痫前期患者胎盘瘦素对血清瘦素水平及缺氧对胎盘瘦素合成的影响

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1、子痫前期患者胎盘瘦素对血清瘦素水平及缺氧对胎盘瘦素合成的影响【关键词】先兆子痫ContributionofplacentalleptintotheserumlevelsinpreeclampsiaandeffectofhypoxiaonsynthesisofplacentalleptinHUANGLiang,LIDongHong,YINGuoWu,ZHAOHongXi,JIANGFeng,YAOYuanQing.DepartmentofObstetrics&Gynecology,TangduHospital,Fou

2、rthMilitaryMedicalUniversity,Xian710038,China.【Abstract】AIM：Toinvestigatethecontributionofplacentalleptintotheserumlevelsandtheeffectofhypoxiaonsynthesisofplacentalleptin.METHODS：Fifteenpreeclampticwomenand20normotensivepregnantwomenwererecruitedinpresentstudy

3、.Leptinconcentrationsinperipheralvenousbloodsamplesanduterinevenousbloodsamplesweremeasuredbyradioimmunoassay.Eightcasesofnormalhumantermplacentalvilliwereculturedeitherinnormaxia(210mL/LO2)orinhypoxia(20mL/LO2)followedbydeterminingleptinintheculturemediumbyra

4、dioimmunoassay.RESULTS:Leptinconcentrationsweresignificantlyhigherinpreeclampticwomenthaninnormotensivepregnantwomen,bothintheperipheralvein(2329±1287μg/Lvs1387±557μg/L,P<005)anduterinevein(1644±862μg/Lvs1121±4.20μg/L,P<005).Leptinconcentrationweresignificantl

5、yhigherintheperipheralveinthaninuterinevein,bothinthepreeclamptic(P<005)andinnormotensivepregnantwomen(P<005).Concentrationsofleptinintheculturemediumweresignificantlyincreasedinhypoxiathaninnormoxia(P<005).CONCLUSION:Thepathogenesisofpreeclampsiamaybeassociat

6、edwithanincreaseofmaternalserumleptinandplacentaleptin,andhypoxiainplacentamaybeanimportantfactorthatresultsinpreeclampticplacentatoproducemoreleptin.Placentaisnottheprincipalsourceoftheserumleptininthepreeclampticwomenornormotensivepregnantwomen.【Keywords】pre

7、eclampsia;leptin;hypoxia【摘要】目的：探讨妊娠期高血压疾病子痫前期患者胎盘与血清瘦素水平的关系及缺氧对胎盘绒毛合成瘦素的影响.方法：应用RIA法测定孕妇肘前静脉及胎盘附着部位子宫静脉血血清瘦素水平，其中妊娠期高血压疾病子痫前期患者(研究组)15例，正常妊娠妇女（对照组）20例；并在缺氧（20mL/LO2）及常氧（210mL/LO2）环境下培养8例正常足月胎盘绒毛，通过RIA法检测胎盘绒毛培养液中瘦素的含量.结果：研究组外周血瘦素水平为2329±1287μg/L，对照组为1387±557μg/

8、L，两组比较差异有统计学意义（P<005）；研究组子宫静脉血瘦素水平为1644±862μg/L，对照组为1121±420μg/L,两组比较有统计学意义（P<005）研究组和对照组外周血瘦素水平均高于子宫静脉血（P<005）.在缺氧条件下胎盘绒毛培养上清中瘦素的含量高于常氧条件下（P<005）.结论:妊娠期高血压疾病患者胎盘及血清中瘦素的水平升高，可能与妊娠期