子痫前期患者胎盘组织瘦素的表达与病情的相关性研究

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1、中国医师进修杂志2010年4月25Et第33卷第l2期ChinJPostgradMed，April252010，Vo1．33，No．12·临床论著·子痫前期患者胎盘组织瘦素的表达与病情的相关性研究高咏梅仵妍【摘要】目的探讨子痫前期患者胎盘组织瘦素的表达水平与病情的关系。方法选择妊娠期高血压疾病患者1O例、子痫前期轻度患者1O例、子痫前期重度患者1O例，采用RT-PCR技术检测患者胎盘组织瘦素mRNA的表达水平，并与15例正常孕妇(对照者)进行比较。同时检测子痫前期患者24h尿蛋白定量及平均动脉压。结果胎盘组织瘦素mRNA表达水平子痈前期重度患者(0．507±0．036)及子痫前期轻度患者

2、(0．476±0．023)均高于对照者(0．441±0．o3o)(p<0．01)，子痫前期重度患者高于子痫前期轻度患者(P<0．05)；妊娠期高血压疾病患者瘦素mRNA表达水平(O．463±0．024)与对照者比较，差异无统计学意义(P>0．05)。子痫前期患者胎盘组织瘦素mRNA表达水平与24h尿蛋白定量、平均动脉压呈正相关(P<0．05)。结论子痫前期患者胎盘组织瘦素表达水平明显升高，且表达水平与病情有关。【关键词】先兆子痫；高血压；瘦素Therelationshipofplacentalexpressionofleptinanddiseasedevelopmentinpatient

3、swithpre-eclampsiaGA0Yong-mei，Yah．DepartmentofGynaecologyandObstetrics，QHaiciHospital，QingJ~o266033，ChinaCorrespondingauthor：GA0Yong-mei，Email：gaoyongmei．666@163．com【Abstract】ObjectiveTostudytherelationshipofplacentalexpressionofleptinanddiseasedevelopmentinpafien~withpre—eclampsia．MethodsTheplac

4、entalexpressionofleptingenewasdeterminedingestationalhypertension(10cages)，mildpre-eclampsia(10cases)，severepre-eelampsia(10cases)andnormalpregnantwomen(15cases，controlgroup)byreversetranscription／polymerasechainreaction(RT／PCR)．Meanwhile，24hoururineproteinandmeanarterialbloodpressure(MAP)weredet

5、ectedinpatientswithpre—eelampsia．ResultsTheexpressionofleptinmRNAinplacentaweresignificantlyhigherinsevereandmildpre·eclampsiathanthatinnormalpregnantwomen(0．507-I-0．036，0．476±0．023VS0．441±O．030)(P<0．01)，meanwhile，intheseverepre·eclampsiawashigherthanthatinthemildpre-eclampsia(P<0．05)．Thediferenc

6、ewaftnotsignifcantbetweenthegestafionalhypertension(0．463±O．024)andthenormalpregnantwomen(P>0．05)．TherewasapositivecorrelationbetweentheplacentalleptinmRNAexpressionlevelsinpre-eclampsiaandthe24hoururineproteinandMAP(P<0．05)．ConclusionsTheplacentalleptinmRNAexpressionlevelinpre-eclampsiaincrease．

7、Thepre-eelampsiawomenplacentalleptinmRNAexpressionlevelscorrelatewithpathogeneticcondition．TheplacentalhptinmRNAexpressionlevelsinpre-eclampsiacorrelatewithdiseasedevelopment．【Keywords】Pre—eclampsia；Hypertension；Leptin