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时间:2020-04-08
《玻璃酸钠联合复方倍他米松治疗膝骨关节炎44例临床观察.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、玻璃酸钠联合复方倍他米松治疗膝骨关节炎44例临床观察2018-11-1501:27:10风湿病与关节炎2018年8期杜立群【摘要】目的:观察玻璃酸钠联合复方倍他米松治疗膝骨关节炎的临床疗效。方法:将88例膝骨关节炎患者随机分为治疗组和对照组,每组44例。对照组给予玻璃酸钠关节腔内注射,治疗组在对照组治疗基础上加用复方倍他米松关节腔内注射。观察2组临床疗效,以及治疗前后视觉模拟评分法(VAS)评分、美国特种外科医院膝关节评分(HSS评分),治疗过程中药物不良反应情况。结果:治疗组显效14例,有效26例,无效4例,总有效率为90.91%:对
2、照组显效10例,有效20例,无效14例,总有效率为68.18%。2组比较,差异有统计学意义(Pv0.05)。治疗7d后,2组VAS评分较治疗前均有降低,且治疗组低于对照组(P<0.05)。治疗5周后,2组HSS评分较治疗前均有升高,且治疗组高于对照组(P<0.05)。2组患者治疗期间均未发生明显药物不良反应。结论:玻璃酸钠联合复方倍他米松关节腔内注射治疗膝骨关节炎疗效显著,可以有效提高患者膝关节功能,缓解疼痛程度,且安全性较高。【关键词】骨关节炎,膝;玻璃酸钠;复方倍他米松;临床疗效ClinicalObservationon44Case
3、sTreatedwithSodiumHyaluronateCombinedwithCompoundBetamethasoneDULi-qun[ABSTRACT]Objective:Toobservetheclinicalefficacyofsodiumhyaluronatecombinedwithcompoundbetamethasoneinthetreatmentofkneeosteoarthritis.Methods:Eighty-eightpatientswithkneeosteoarthritiswererandomlydivi
4、dedintoatreatmentgroupandacontrolgroup,44casesineachgroup.Thecontrolgroupwasgivenintra-articularinjectionofsodiumhyaluronate,andthetreatmentgroupwasgivenintra-articularinjectionofcompoundbetamethasoneonthebasisofthetreatmentforthecontrolgroup.Theclinicalefficacy,visualan
5、aloguescale(VAS),HospitalforSpecialSurgeryKneeScore(HSS)andadversedrugreactions(ADR)wereobservedbeforeandaftertreatment.Results:Inthetreatmentgroup,14casesweremarkedlyeffectiver26caseswereeffective,4caseswereineffective,andthetotaleffectiveratewas90.91%,whileinthecontrol
6、group,10casesweremarkedlyeffective,20caseswereeffective,14caseswereineffectiveandthetotaleffectiveratewas68.18%.Thedifferencebetweenthetwogroupswasstatisticallysignificant(P<0.05)・After7daysoftreatment,theVASofthetwogroupswaslowerthanthatbeforetreatment,andthatofthetreat
7、mentgroupwaslowerthanthecontrolgroup(P<0.05).After5weeksoftreatment,theHSSofthetwogroupswashigherthanthatbeforetreatment,andthatofthetreatmentgroupwashigherthanthecontrolgroup(P<0.05).Noobviousadversereactionswereobservedinthetwogroupsduringtreatment.Conclusion:Intra-art
8、icularinjectionofsodiumhyaluronatecombinedwithcompoundbetamethasoneiseffectiveinthetreatmentofkneeosteo
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