医药学临床医学毕业论文 玻璃酸钠联合复方倍他米松治疗强直性脊柱炎髋关节病变33例临床疗效观察

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1、湖南师范大学本科毕业论文考籍号：XXXXXXXXX姓名：XXX专业：医药学临床医学论文题目：玻璃酸钠联合复方倍他米松治疗强直性脊柱炎髋关节病变33例临床疗效观察指导老师：XXX二〇一一年十二月十日【摘要】目的观察玻璃酸钠联合复方倍他米松髋关节腔内注射方法对强直性脊柱炎髋关节病变的临床治疗效果。方法63例强直性脊柱炎伴髋关节病变患者随机分为两组，均在给予柳氮磺吡啶1.0g，每日2次及萘丁美酮1.0g，每日1次的基础治疗上，试验组患者进行玻璃酸钠和复方倍他米松髋关节腔内注射，每周1次，第1周同时注射两种药物，后第2～5周，仅注射玻璃酸钠，而对照组仅于疗程第1天给予复方倍他米

2、松肌肉注射1次，连续5周为1个疗程。记录观察治疗前后髋关节疼痛程度、指－地距离、百米步行时间、实验室指标以及髋关节Ⅹ线变化。结果试验组在髋关节疼痛的缓解和髋关节功能的改善方面均优于对照组，治疗前后的差值差异有显著性（P0.05或P0.01）；在延缓髋关节结构破坏方面试验组恶化率为15.2%，而对照组仅为36.7%，差异有显著性（P0.01）。结论玻璃酸钠联合复方倍他米松髋关节腔内注射是治疗强直性脊柱炎髋关节病变安全、有效的方法，尤其适合早、中期的髋关节病变患者。【关键词】玻璃酸钠;复方倍他米松;关节腔内注射;强直性脊柱炎;髋关节病变Effectofcombinedint

3、ra-articularinjectionofsodiumhyaluronateandcompoundbetamethasoneoncoxaarthropathyin33patientswithankylosingspondylitis【Abstract】ObjectiveTostudytheclinicaleffectofcombinedintra-articularinjectionofsodiumhyaluronateandcompoundbetamethasoneonhiparthropathyinpatientswithankylosingspondyliti

4、s(AS).Methods63casesofcoxaarthropathyassociatedwithASweredividedintotwogroups,experimentalgroup(EG)andcontrolgroup(CG).Bothgroupsreceivedabasaltreatmentoftakingsulfasalazineandnabumetone.InEGintra-articularinjectionofsodiumhyaluronateandwascarriedoutonceaweekin33patientswithcoxaarthropat

5、hyassociatedwithAS.Eachcasereceived5injectionsinall,onlyinfirstinjectioncombinedwithcompoundbetamethasone.The30patientsinCGweregivenonlyoneinjectionofcompoundbetamethasoneintramuscularlyatfirstdayofthetreatment.Clinical,laboratoryandⅩ-raydataofthepatientswerecollectedbeforeandaftertreatm

6、ent.ResultsEGoutstripsCGinrelievingcoxaarthropathyandimprovingthefunctionofhipjoint(P005andP001).36.7%ofcasesinCGgotworseand15.2%inEGindisorganizationofhipjoint(P001).ConclusionCombinedintra-articularinjectionofsodiumhyaluronateandcompoundbetamethasoneweresafeandeffectiveinthetreatmen

7、tofcoxaarthropathyinpatientswithAS,especiallyfittingforearlyandmetaphasecoxaarthropathyassociatedwithAS.【Keywords】sodiumhyaluronate;compoundbetamethasone;intra-articularinjection;ankylosingspondylitis;coxaarthropathy强直性脊柱炎(ankylosingspondylitis,AS)是一种常见的血清阴性脊柱关节病，髋关节受累常见,