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1、超声引导下外科微创封堵治疗巨大房间隔缺损的临床研究【摘要】目的：研究及分析超声引导下外科微创封堵治疗巨大房间隔缺损的临床效果。方法：选取2013年4月-2015年2月于本院进行治疗的40例巨大房间隔缺损患者为研究对象，将其按随机数字表法随机分为A组（微创封堵治疗）20例和B组（常规手术治疗）20例，然后将两组患者的手术时间、术后住院时间、输血情况、并发症发生率、住院费用、切口大小及手术前后的炎性因子、心脏相关指标进行比较。结果：A组的手术时间及术后住院时间均短于B组，输血率及并发症发生率低于B组，住院费用高
2、于B组，切口小于B组，而术后不同时间点的炎性因子血清表达水平低于B组，比较差异均有统计学意义（1X0.05）,而两组患者不同时间的心脏相关指标比较差异无统计学意义，但均好于术前（P〈0・05）。结论：超声引导下外科微创封堵治疗巨大房间隔缺损的临床效果较好，且对于患者的炎症反应控制相对更好，更为适用于此类患者的治疗。【关键词】超声引导下外科微创封堵治疗；巨人房间隔缺损；临床效果；炎症反应[Abstract】Objective：Tostudyandanalyzetheclinicaleffectofminima
3、llyinvasivesurgicaltreatmentofminimallyinvasivesurgicalclosuretreatmentguidedbyultrasoundinthetreatmentofpa/tientswithlargeatrialseptaidefect.Method：40patientswithlargeatrialseptaldefectinourhospitalfromApril2013toFebruary2015wereselectedasthestudyobjects,
4、andtheywererandomlydividedintogroupA(minimallyinvasivesurgicalclosuretreatment)for20casesandgroupB(conventionaloperationtreatment)for20cases,thentheoperationtime,postoperativehospitalizationtime,transfusioncondition,complicationrates,hospitalizationexpense
5、s,incisionsize,inflammatoryfactorsandcardiacrelatedindexesbeforeandaftertheoperationofthetwogroupswerecompared.Result：TheoperationtimeandpostoperativehospitalizationtimeofthegroupAwasshorterthanthatofthegroupB,thetransfusionrateandcomplicationratewaslower,
6、hospitalizationexpenseswashigher,incisionsizewassmaller，andtheinflammatoryfactorsserumexpressionatdifferenttimeaftertheoperationwasal11owerthanthatofthegroupB(P<0.05),whilethecardiacrelatedindexesofthetwogroupsatdifferenttimeaftertheoperationhadnoobviousdi
7、fferences,butthatwasallbetterthanthelevelbeforetheoperation(P〈0.05).Conclusion：Theclinicaleffectofminimallyinvasivesurgicaltreatmentofminimal1yinvasivesurgicalclosuretreatmentguidedbyultrasoundinthetreatmentofpatientswithlargeatrialseptaldefectarebetter,an
8、ditscontrolfortheinflammatorj^responsearerelativelybetter,soitismoresuitableforthetreatmentofthesepatients[Keywords]Minimallyinvasivesurgicalclosuretreatmentguidedbyultrasound；Largeatrialseptaldefect；Clinical
