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1、中国误诊学杂志2010年7月第10卷第21期ChinJMisdiagn,Jul2010Vol10No.215047【研究原著】绝经前乳腺癌ER、PR、c2erbB22的表达与血清E2水平及临床病理相关性分析121郑清存,陈瑞英,杨超【摘要】目的探讨绝经前乳腺癌ER、PR、c2erbB22表达与患者血清E2水平及临床病理因素的关系。方法使用免疫组化SP二步法检测绝经前乳腺癌患者84例ER、PR、c2erbB22表达状态并与血清E2水平及临床病理资料进行相关性分析。结果ER、PR、c2erbB22表达与E2无显著相关(P>0105);乳腺癌组织分级、TNM分期均与ER、PR负相关(P<0105);
2、组织分级、腋淋巴结转移、TNM分期、肿瘤大小均与c2erbB22正相关。结论绝经期前乳腺癌患者ER、PR、c2erbB22表达可能与雌激素水平无关;可能与乳腺癌的组织学分级、腋淋巴结转移、TNM分期和肿瘤大小相关,可联合应用,作为绝经期前乳腺癌患者指导内分泌治疗和预后的指标。【主题词】绝经前期;乳腺肿瘤/代谢;受体,雌激素/代谢;基因,erbB-2;人类;女(雌)性【中图分类号】R737.9【文献标识码】A【文章编号】100926647(2010)2125047203StudyonRelationshipbetweenExpressionLevelofEstrogenReceptor,Prog
3、esteronerecPetor,c2erbB22GenesandSerumEstrogenLevel,ClinicalPathologyinPatientswithPre2menopausalBreastCanc2ersZHENGQing2cun,CHENRui2ying,YANGchao.TangshanMaternityandChildHealthCareHospital,Tangshan063000,China【Abstract】ObjectiveToinvestigatetherelationshipbetweentheexpressionlevelofER,PR,c2erbB22g
4、enesandserumE2level,clinicalpathologyinthepatientswithpre2menopausalbreastcancers.MethodsTheexpressionsofER,PRandc2erbB22genesweredetectedbytwo2stepimmunohistochemistryin84premenopausalfemalepa2tientswithprimarybreastcancer.TherelationshipofserumE2level,theclinicalpathologywerecomparedandana2lyzed.R
5、esultsAmongtheprognosisindicatorsofbreastcancer,theexpressionlevelofER,PR,c2erbB22geneswerenotsignificantlycorrelatedwithandserumE2level(P>0105),histologicalgradeofbreastcancer,Tumor,nodes,metastasis2classification(TNM)stagingwerenegativelycorrelatedwithERandPR(P<0105).Histologicalgradeofbreastcance
6、r,axillarylymphnodemetastasis,tumor,nodes,metastasis2classification(TNM)staging,thesizeoftumorwerepositivecorrelatedwithc2erbB22genes(P<0105).ConclusionInbreastcancerpatientsbeforemeno2pause,theER,PR,c2erbB22genesexpressionlevelarenotpossiblycorrelatedwiththeserumE2levelandcorrelatedwithhistological
7、grade,axillarylymphnodemetastasis;tumor,nodes,metastasis2classification(TNM)stagingandthesizeofoftumor.【MeSH】Premenopause;BreastNeoplasms/metabolism;Receptors,Estrogen/metabolism;Genes,erbB22;Humans;F
