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《板栗刺刺伤所致真菌性角膜炎14例临床分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·816·疑难病杂志2014年8月第13卷第8期ChinJD幽candComplCas,August2014,V0J.13No.8【摘要】目的探讨板栗刺所致真菌性角膜炎患者的溃疡形态、致病菌属及治疗特点。方法回顾性分析2011年9月—013年l2月收治的14例(14眼)板栗刺所致真菌性角膜炎患者的临床资料,根据溃疡形态分上皮型、基质脓肿型、内皮或前房型,真菌培养获取病原学结果,并根据溃疡类型采用那他霉素+氟康唑+伊曲康唑三联抗真菌药物治疗联合溃疡板层清创、两性霉素B角膜基质注射、平衡盐液前房冲洗及两性霉素B前房注射等手术干预措施,观察治
2、疗效果及预后。结果14例患者中l0例真菌培养结果阳性,链格霉菌及镰刀霉菌各4例,青霉菌及曲霉菌各1例;溃疡分型:上皮型7例,基质脓肿型2例,内皮或前房型5例;上皮型对三联抗真菌药物治疗敏感,联合溃疡板层清创术治疗后有效率为100%(7/7);基质脓肿型、内皮或前房型对单纯三联抗真菌药物治疗基本无效,联合两性霉素B基质注射或前房冲洗及两性霉素B前房注射后治疗有效率为85.7%(6/7)。14例均未见严重并发症。结论板栗刺所致真菌性角膜炎在溃疡形态上具有多样性,致病菌属以链格霉菌和镰刀霉菌为主,临床上根据溃疡类型采取抗真菌药物治疗联合恰当的
3、手术干预可取得良好的治疗效果。【关键词】板栗刺;真菌;角膜溃疡;抗真菌药物;手术干预【DOI】10.3969/j.issn.1671-6450.2014.08.017Theclinicalanalysisof14casesoffungalkerafifiscausedbyChinesechestnutthornsCHENGJinkui,YANGYanning,YUANJing,WANShanshan,ZHAOWei.TheOphthalmologyCenter,RenminHospitalWuhanUniversity,HubeiPro
4、vince,Wuhan430060,ChinaCo~espondingauthor:YANGYanning,E—mail:ophyyn@163.corn【Abstract】ObjectiveToexplorethefeaturesandtreatmentofulcermorphological,pathogenicbacteriaoffungalkeratitiswhichiscausedbychestnut.MethodsFrom2011Septemberto2013December,retrospectiveanalysisclin
5、icaldata0f14cases(14eyes)offungalkeratitiswhichwerecausedbychestnut,accordingtotheulcermorphology,theywereclassi—fledasepithelialtype,matrixabscesstype,endothelialoranteriorchambertype;usingoffungalculturetoobtainetiologicalresults,andaccordingtothetypeoftheulcer,natamyc
6、in+itraconazole+fluconazoleantifungaldrugtherapycombinedwithulcercombinedlamellardebridement,amphotericinBintrastromalinjection,balancedsaltsolutionforirrigationofanteriorchamberandamphotericinBanteriorchamberinjectionoperationinterventionwereperformed,andobservethethera
7、peuticeffectandprognosis.ResultsAmongthe14patients,10caseswithfungalculturepositiveresults,AhernariafungiandFu—sariumsp.werefoundin4casesseparately,PenicilliumandAspergilluswerein1caseseparately;ulcertypes:epithelialtypein7cases,2casesofstromalabscesstype,5casesofendothe
8、lialorepithelialtypeontheanteriorchamber;antifungaldrugwassensitiveforepithelialtype.combinedwithplatel
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