超声检测模拟失重状态对女性血管内皮功能的影响.pdf

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1、临床超声医学杂志2012年4月第14卷第4期JClinUlwasoun—d—in：卫1：：垒：·237··l】盘床研究·超声检测模拟失重状态对女性血管内皮功能的影响贾化平何薇薇梁会泽魏相东孙志英摘要目的应用高分辨率超声检测模拟失重状态对女性肱动脉血流介导的血管内皮功能的影响。方法青年女性志愿者22例，采用一6o头低位持续卧床模拟失重状态，持续21d。模拟失重开始前1d及模拟失重第21天为血管内皮功能的超声检测时点。测量前臂充气加压前后肱动脉的内径变化率，评价血流介导的肱动脉血管内皮功能。结果所有志愿者均按照要求完成模拟失重任务，

2、在模拟失重开始前1d及模拟失重第21d超声检测可获得满意图像。与模拟失重开始前Id比较，模拟失重第21天志愿者肱动脉血流介导的内皮舒张功能降低，差异有统计学意义(P<0．05)。结论模拟失重降低了女性志愿者肱动脉血流介导的内皮舒张功能，血流介导的内皮舒张功能下降可能参与模拟失重状态心血管系统的去适应机制。关键词超声检查，高分辨率；模拟失重；内皮功能，血管，血流介导[中图法分类号]R445．1[文献标识码]AEfectofsimulatedweightlessnessonfemale’Svascularendothelialfun

3、ctionevaluatedbyultrasoundJIAHuaping，HEWeiwei，LIANGHuize，WEIXiangdong，SUnZhiyingDepartmentofSpecialDiagnosis，the306thHospitalofPLA，Beijing100101，ChinaABSTRACTObjectiveToexploretheefectofsimulatedweightlessnessonfemale’Sflow—mediatedvascularendothelialfunctionofbrachi

4、alarterybyhigh—resolutionultrasound．MethodsTwenty—twoyoungfemalevolunteerswereinvolvedin出isstudy。weightlessnessconditionwassimulatedbycontinuous一6。headdowntiltbedrestandlastedfor21days．Vascularendothelialfunctionofbrachialwasexaminedatthefirstdaybeforethebeginningofs

5、imulatedweightlessnessandthe21stdayofsimulatedweightlessness．Theinternaldiametersofbrachialarteryweremeasuredbyhigh—resolutionultrasoundbeforeandafterinflation，andthechangerateoftheinternaldiameterwascalculated．ResultsA11volunteersfulfilledtheexperiment．andsatisfying

6、imagesweregottenatthefirstdaybeforethebeginningofsimulatedweight]essnessandthe21stdayofsimulatedweightlessness．Comparedwiththefirstdaybeforethebeginningofsimulatedweightlessness，theflow-mediatedvascularendothelialfunctionwasdeterioratedat21stdayofsimulatedweightlessn

7、ess。therewassignificantdifference(P<0．05)．ConclusionSimulatedweightlessnesscoulddeteriorateflow—mediatevascularendothelialfunction．andfurtherstudyiSstillneededtofindwhetherabnormalvascularendothelialfunctioniSinvolvedinthemechanismsofaerodeadaptation．KEYWORDSUhrasono

8、graphy，high-resolution；Simulatedweightlessness；Endothelialfunction，vaseulo2",flow—mediated航天微重力环境可引起心血管系统形态和功能的年龄19—23岁，平均(21．0±1．3