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1、血液净化联合前列地尔及奥Illi肽治疗高脂血症胰腺炎的临床研究[摘要]目的研究血液净化(continuousbloodpurification,CBP)联合前列地尔注射液及醋酸奥曲肽治疗高脂血症胰腺炎的疗效。方法50例高脂血症胰腺炎患者分成观察组和对照组。对照组:醋酸奥曲肽;观察组:醋酸奥1川肽+前列地尔注射液+CBP。结果观察组显效率(80.00%)、总有效率(96.00%)高于对照组显效率为(48.00%)、总有效率(68.00%),差异有统计学意义(P<0.05);观察组治疗5d后血淀粉酶阴转率为80.00%高于对照组
2、血淀粉酶阴转率48.00%,差异有统计学意义(PV0.05)。两组不良反应发生率差异无显著性(P>0.05)。结论CBP联合前列地尔注射液及醋酸奥曲肽治疗高脂血症胰腺炎疗效可靠,安全,值得临床应用推广。[关键词]血液净化;前列地尔;醋酸奥曲肽;高脂血症腹腺炎[中图分类号]R589.2;R657.5+1[文献标识码]B[文章编号]1673-9701(2011)24-95-02ClinicalResearchofCBPandAlprostadilandOctreotideAcetateTreatmentofHyperlipoid
3、emiaAcutePancreatitWEIGuijunHUYiYANGYongDigestingInternalMedicineDepartment,theFirstPeople'sHospitalinHuzhouCityofZhejiangProvince,Huzhou313000,China[Abstract]ObjectiveTostudytheefficacyresearchofCBPandalprostadilandoctreotideacetatetreatmentofhyperlipoidemiaacutep
4、ancreatit.MethodsAU50casesofhyperlipoidemiaacutepancreatitweredividedintoobservationgroupandcontrolgroup.Controlgroup:octreotideacetate;ObserverGroup:octreotideacetate+alprostadil+CBP.ResultsSignificantefficiencyoftheobservationgroup80.00%,thetotaleffective96.00%bi
5、ggerthansignificantefficiency48.00%thetotaleffective68.00%ofcontrolgroup,differencewasstatisticallysignificant(P<0.05);Treatmentforfivedays,bloodamylaseyinturnratetheobservationgroup80.00%than48.00%incontrolgroup,therewasstatisticallysignificantdifference(P<0.05).T
6、wogroupsadversereactionratehadnosignificantdifference(P>0.05).ConclusionCBPandalprostadilandoctreotideacetatetreatmentofhyperlipoidemiaacutepancreatitisgoodefficacy,fewadversereactions,affordable,worthofclinicapplicationpromotion.[Keywords]CBP;Alprostadil;Octreotid
7、eacetate;Hyperlipoidemiaacutepancreatit目前高脂血症胰腺炎的发病率逐年上升,己成为临床急性胰腺炎发生的第二大病因[1]。本文中,笔者采用血液净化(continuousbloodpurification,CBP)联合前列地尔注射液及醋•酸奥曲肽治疗高脂血症胰腺炎,取得较好的疗效,现报道如下。1对象与方法1.1研究对象木课题所选病例50例,全部来源于2008年6月〜2011年6月在我院就诊的高脂血症胰腺炎患者,年龄29~68岁,平均(41.5±14.6)岁。纳入标准:具有胰腺炎的临床表现,诊
8、断及轻重分型参照我国2003年急性胰腺炎诊治指南[2];TG&11.3mmol/L或TG在(5.65〜11.3)mmol/L,血清呈乳糜状。排除标准:试验用药过敏者;伴有肝、肾等其他严重器质性疾病者。按就诊顺序采用随机分组法,设立观察组(CBP联合前列地尔及奥曲肽)、对照组(奥曲肽)。观察