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《补肾清透方对慢性乙肝HBeAg阳性患者血清IL-2、IL-4、IL-10、TNF-α及IFN-γ的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、国际检验医学杂志2014年3月第35卷第5期IntJLabMed,March2014,Vo1.35,No.5·565··临床检验研究论著·补肾清透方对慢性乙肝HBeAg阳性患者血清IL一2、IL一4、IL一1O、TNF—及IFN一7的影响刘心亮,熊益群,周大桥,童光东,贺劲松,张晓晖徐绍钢,穆桂萍,刘文赫(广州中医药大学附属深圳医院中心实验室肝病科,广东深圳518033)摘要:目的观察补肾清透方治疗慢性乙型肝炎(CHB)乙型肝炎e抗原(HBeAg)阳性患者外周血中白细胞介素一2(II一2)、白细胞介素一4(IL一4)、白细胞介素一10(IL—lO)、肿瘤坏死因
2、子Q(TNF_)和干扰素一(IFN一7)的变化。方法6O例CHBHBeAg阳性患者被随机分成治疗组和对照组,每组3O例,CHB治疗组接受补肾清透方治疗,疗程48周,CHB对照组不接受药物治疗。分别在开始和第48周时两组患者抽血检测HBVDNA、II一2、II一4、II一10、TNF-a和IFN一7。结果CHB治疗组治疗后与治疗前比较,II一2、TNF—d、IFN一7明显升高,HBVDNA、II一4、II一lO明显下降(PO.05)。结论补肾清透方能抑制CHBHBeAg阳性患者HBVDNA复
3、制,可提高机体的细胞免疫功能。关键词:补肾清透方;肝炎,乙型,慢性;细胞因子类DOI:10.3969/j.issn.1673—4130.2O14.05.024文献标识码:A文章编号:1673—4130(2014)05—0565—03InfluenceofBushenqingtOuDecoctiononserumIL一2,IL一4,IL一10,TNF-aandIFN—YinchronichepatitisBpatientswithpositiveHBeAgLiuXinliang,XiongYiqun,ZhouDaqiao,TongGuangdong,HeJing
4、song,ZhangXiaohui,XuShaogang,MuGuiping,LiuWenhe(DepartmentoJHepatology,CentralLaboratory,AffiliatedShenzhenHospital,GuangzhouUniversityofChineseMedicine,Shenzhen,Guangdong518033,China)Abstract:ObjectiveToobservethechangesofperiphera1bloodinterleukin一2(II一2),interleukin一4(II一4),inter
5、leukin一10(II一10),tumornecrosisfactoralpha(TNFa)andinterferongamma(IFN一7)inchronichepatitisB(CHB)patientswithpositivee—antigen(HBeAg)treatedbyBushenqingtouDecoction.Methods60casesofCHBwithpositiveHBeAgwererandomlvdiv~dedintothetreatmentgroupandthecontrolgroup,30casesineachgroup.TheCH
6、BtreatmentgroupreceivedBushenqingtouDecoctionwiththetreatmentcourseof48week,whiletheCHBcontrolgroupdidnotreceivedthemedicationtherapy.Inthebeginningandat48weeksoftreatment,thebloodinthetwoCHBgroupswerecollectedfordetectingHBVDNA,IL一2,II一4,II一10,TNF-andIFN一.y.ResultsComparedwithbefor
7、etreatments,thelevelsofIL-2,TNF—dandIFN一7aftertreatmentsintheCHBtreatmentgroupwereobviouslyincreased,whilethelevelsofHBVDNA,IL一4andII一10wereremarkablydecreased(P005).Conclusi
8、onBushenqingtou.Dec
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