记忆抱怨主诉与客观认知功能及中医肝郁证的相关性.pdf

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1、中医杂志2012年4月第53卷第7期JournalofTraditionalChineseMedicine，2012，Vo1．53，No．7·591·证候·诊抱怨主诉与客观认知功能及中医肝郁证的相关性彭朗戴中柳洪胜白文龚华强王少杰断．记(北京大学人民医院中医科，北京市西直门南大街11号，100044)乙基金项目：2008年度中医药行业科研专项项目(200807011)*通讯作者：wsj一51@163．com，(010)88325884[摘要]目的探讨中老年人记忆抱怨主诉(SMC)与客观认知损害、

2、抑郁状态及中医肝郁证候因素的关系。方法临床招募SMC受试者102例，分为SMC认知正常组(52例)与SMC认知下降组(50例)，并选择无SMC且客观认知功能正常的对照组(2O例)，分别进行记忆抱怨主诉视觉评价量表(SMC-VAS)自评，简易智能精神状态检查量表(MMSE)、蒙特利尔认知评定量表(MoCA)客观认知功能评价，汉密尔顿抑郁量表(HAMD-17)抑郁状态评价，及中医肝郁相关证候调查。结果SMC认知正常组HAMD-17平均得分高于SMC认知下降组和对照组(P<0．05和P％0．01)；S

3、MC认知正常组中医肝郁相关证候平均得分高于SMC认知下降组(P<0．05)；SMC认知正常组SMC-VAS总分与MoCA总分无明显关联，与HAMD-17得分(P

4、记忆抱怨主诉；蒙特利尔认知评定量表；抑郁状态；健忘；肝郁证CorrelationbetweenSubjectiveMemoryComplaint，ObjectiveCognitiveImpairmentandChineseMedicalSyndromeofLiverDe‘pressionPENGLang，DAIZhong，LIUHongsheng，BAIWen，GONGHuaqiang，WANGShaojie．(PekingUniversityPeople'sHospital，Beijing10

5、0044)ABSTRACTObjectiveTodiscussthecorrelationbetweensubjectivememorycomplaint(SMC)，objectivecognitiveimpair—ment，depressionandChinesemedicalsyndromeofliverdepressionintheelderly．MethodsTotally102participantswithSMCand20normalcognitivefunctionalcontro

6、lswithoutSMCwererecruited．The102SMCpatientsweredividedintoSMCwithnormalcognition(52cases)andSMCwithdecreasedcognition(5Ocases)．ParticipantswereaskedtoratethedegreeoftheirperceivedcognitivedeclinebySubjectiveMemoryComplaintVisualRatingScale(SMC—VAS)．T

7、heobjectivecognitivefunctionwasexaminedbyusingMini-MentalStateExamination(MMSE)andMontrealCognitiveAssessment(MoCA)．De—pressionwasassessedbyusingHamiltonDepressionRatingScale(HAMD-17)andChinesemedicalsyndromeofliverdepres—sionwasalsoinvestigated．Resu

8、ltsTheHAMD-17scoresinSMCcognitivelynormalgroupweresignificantlyhigherthanthoseinSMCcognitivedeclinegroupandthecontrolgroup(P