黄葵胶囊联合银杏达莫治疗慢性肾脏病的临床效果观察.pdf

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1、2013年11月第2O卷第32期·药物与临床·黄葵胶囊联合银杏达莫治疗慢性肾脏病的临床效果观察戴建华江苏省泰州市第四人民医院内科．江苏泰州225300【摘要】目的探讨黄葵胶囊联合银杏达莫治疗慢性肾脏病(CKD)的效果。方法将48例CKD患者随机分成常规治疗组(A组)、常规治疗+黄葵胶囊组(B组)、常规治疗+黄葵胶囊+银杏达莫组(C组)，观察各组患者治疗前后24h尿蛋白、血尿素氮、血肌酐、总胆固醇、三酰甘油、全血黏度、血浆黏度及临床症状积分。结果治疗后各组患者的24h尿蛋白水平差异有统计学意义(P

2、=0．04)，且B、C组的24h尿蛋白水平明显低于A组，C组明显低于B组，差异均有统计学意义(P<0．01)；治疗后3组患者的血尿素氮、血肌酐、总胆固醇、三酰甘油、全血黏度、血浆黏度水平均有所下降，但A、B组差异无统计学意义(P>0．05)，C组与A、B组差异有统计学意义(P<0．05)。结论黄葵胶囊联合银杏达莫可降低尿蛋白水平，改善肾小管功能，抑制肾小管纤维化，延缓CKD的进展。【关键词】黄葵胶囊；慢性肾脏病；尿蛋白【中图分类号】R692【文献标识码】A【文章编号】1674—4721(2013

3、)11(b)一0073—03Clinicaleficacyobservationofabelmoskcapsulescombinedwithginkgo-damoleintreatmentofchronickidneydiseaseDAIJian——huaDepartmentofInternalMedicine，theFourthPeopleSHospitalofTaizhouCityinJiangsuProvince，Taizhou225300，China[Abstract]Objective

4、Toinvestigatetheefficacyofabelmoskcapsulescombinedwithginkgo-damoleinthetreatmentofchronickidneydiseaserCKD)．Methods48cases0fpatientswithCKDwererandomlydividedintoconventionaltreatmentgroup(groupA)，conventionaltreatment+abelmoskcapsulesgroup(groupB)a

5、ndconventionaltreatment+abel—moskcapsules+ginkgo-damolegroup(groupC)．Thescoresof24-,hoururineprotein，bloodureanitrogen，bloodcreati—nine，totalcholesterol，triglycerides，wholebloodviscosity，plasmaviscosityandclinicalsymptomsofbothgroupsbeforeandaftertre

6、atmentwereobserved．ResultsAfterthetreatment，the24-hoururineproteinlevelswerestatisticallydif-ferentbetweenthe3groups(P=0．04)，groupBandgroupChadsignificantlylower24-hoururineproteinlevelsthanthatofgroupA，andgroupChadsignificantlylowerlevelthanthatofgr

7、oupB，withstatisticallysignificantdifferences(尸<0．01)．Afterthetreatment，the24-hoururineprotein，bloodcreatinine，totalcholesterol，triglycerides，wholebloodvis—cosityandplasmaviscositylevelsofallthe3groupsdecreased，butgroupAandgroupBwerenotstatisticallydi

8、fferent(P>O．05)，andgroupCwasstatisticallydifferentfromgroupAandgroupB(P<0．05)．ConclusionAbelmoskcapsulescombinedwithginkgo-damolecanreduceurineprotein，improverenaltubulefunction，inhibitrenaltubulefibrosisandprolongprogressionofchronickidneydiseases．[