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《血清总胆固醇及总胆汁酸检测对肝病诊断的临床意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2420现代医药卫生2014年8月30日g30卷第16期JModMedHealth,August30,2014,Vo1.30,No.16·论著·血清总胆固醇及总胆汁酸检测对肝病诊断的临床意义蹇洁,赵敏(通江县中医医院检验科,四川通江636700)【摘要】目的探讨肝病患者血清总胆固醇(TC)、总胆汁酸(TBA)检测的临床意义。方法选择2012年2月至2013年l0月在该院确诊为肝硬化的86例患者设为肝硬化组,确诊为肝癌的84例患者设为肝癌组,另选择8O例同期健康体检者设为对照组,检测血清TC与TB
2、A水平,对三组检测结果进行统计学分析。结果与对照组比较,肝硬化组和肝癌组血清TC水平明显降低。差异有统计学意义(氏0.05),而TBA水平明显升高,差异有统计学意义(P<0.05);在肝硬化组Child.Pugh分级中.C级患者的血清TC水平最低,分别与A级和B级两两比较,差异均有统计学意义(P<0.05),但A级与B级比较,差异无统计学意义(P>0.05);血清TBA在肝硬化组的A、B、C级中两两比较,差异均有统计学意义(P<0.05),且其水平随着肝功能Child—Pugh分级的增高而升高。
3、结论肝病患者TC、TBA水平均能敏感反映肝损伤的进展情况.是诊断肝病的良好指标,2项指标联合检测可以提高肝硬化疾病的灵敏度,降低漏诊率。I关键词】肝病;胆固醇;总胆汁酸;肝功能分级doi:10.39696.issn.1009—5519.2014.16.008文献标识码:A文章编号:1009—5519(2014)16—2420—02ClinicalsignificanceofserumTCandTBAdetectionfordiagnosisofhepatopathy∞Jie,ZhaoMin(De
4、partmentofClini—calLaboratory,TongfiangHospitalofTraditionalChineseMedwine,Ton~iang,Swhuan636700,China)【Abstract】0bjectiveToexploretheclinicalsignificanceofthedetectionofserumtotalchoesterol(TC)andtotalbileacid(TBA)forhepatopath.MethodsAtotalof86pati
5、ents,whowerediagnosedwithcirrhosisfromFebruary2012toOctober2013,wereselectedascirrhosisgroup,simuhaneously,other84patientsdiagnosedwithlivercancerweretakenascancergroup,andother70healthysubjectswerechosenascontrolgroup.TodetectthelevelsofsenlmTCandTB
6、A,andtheresultsofthethreegroupswereanalyzedstatistically.ResultsComparedwiththecontrolgroup,theserumTClevelreducedapparentlyinbotheir—rhosisgroupandcancergroupwithstatisticallysignificantdifference(P7、ticallysignificantdiference(P<0.05).AccordingtoChild—Pughclassificationincirrhosisgroup,theserumTCinthepatientswithGradeCwasthelowest,whichcomparedwiththeGradeAandGradeBrespectively,thediferencedshowedstatisticalsignifi—cance(P<0.05),butthedifference8、betweenGradeAandGradeBhadnostatisticalsignificance(P>0.05);moreover,pairwisecornpanisonofserumTBAlevelamongGradeA,GradeBandGradeCincirrhosisgrouphadstatisticallysignificantdifference(P
7、ticallysignificantdiference(P<0.05).AccordingtoChild—Pughclassificationincirrhosisgroup,theserumTCinthepatientswithGradeCwasthelowest,whichcomparedwiththeGradeAandGradeBrespectively,thediferencedshowedstatisticalsignifi—cance(P<0.05),butthedifference
8、betweenGradeAandGradeBhadnostatisticalsignificance(P>0.05);moreover,pairwisecornpanisonofserumTBAlevelamongGradeA,GradeBandGradeCincirrhosisgrouphadstatisticallysignificantdifference(P
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