小儿过敏性紫癜与食物不耐受IgG抗体检测及意义.pdf

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1、医学临床研究2013年7月第3O卷第7期JCIinRes，Ju1．2013，Vol30，№7·论著·小儿过敏性紫癜与食物不耐受IgG抗体检测及意义刘莉陈志勇欧阳红娟赵红梅罗艳红唐硕张文婷游洁玉(湖南省儿童医院消化内科，湖南长沙410007)[摘要]【目的】分析过敏性紫癜患儿血清中食物过敏原特异性IgG抗体升高的程度及分布，了解过敏性紫癜患儿与食物的相关性。【方法】收集100倒临床诊断为过敏性紫癜的患儿作为研究对象，50例健康儿童设为对照，用酶联免疫吸附试验(ELlSA)检测其血清中l4种食物过敏原特异性IgG抗体，并对比抗过敏及饮食治疗前后食物不耐受IgG抗体情况。【结果197

2、例过敏性紫癜患儿中有1～6种不等的食物特异性IgG出现升高，阳性率97(97／100)，明显高于正常儿童(97VS2O，PdO．01)。过敏性紫癜患儿血清中14种食物特异性IgG阳性分布以牛奶最高，蛋清／蛋黄次之；鸡肉、猪肉最低。抗过敏药物治疗及饮食指导后，食物特异性G抗体阳性病例数明显降低(Pd0．01)。【结论】过敏性紫癜患儿体内多存在食物不耐受IgG抗体，且可多种同时存在，以牛奶、蛋清／蛋黄最为多见，食物可能是导致过敏性紫癜的原因之一。正确的饮食指导是预防和治疗小儿过敏性紫癜的重要方法。[关键词]紫癜，过敏性；免疫球蛋白GDetectionofIgGAntibodyinC

3、hildrenwithAllergicPurpuraandFoodIntoleranceandItsSignifi—canceLIULi，CHENZhi—yot~g’，(叉n?ANGHong-juan，etal(DepartmentofGastroenterology，Children'sHospita1ofHunanProvince，Changsha410007，China)[Abstract]【()bjective】Toanalyzetheincreasingdegreeanddistributionoffoodallergenspecific-IgGantibodiesi

4、nse—rumofehildrenwithallergicpurpuraandunderstandthecorrelationofallergicpurpuraandfood．[Methods]Totally100childrenclinicallydiagnosedasallergicpurpurawerechosenasstudysubjects，andother5Ohealthychildrenwerechosenascontrols．ELISAwasusedtOdetect14kindsoffoodintolerance—associatedIgGantibodiesi

5、nserum．IgGantibodieswerecomparedbeforeandafterantianaphylaxisanddiettherapy．[Results]The1-6kindsoffoodspecific-IgGin97chil—drenwithallergicpurpuraincreased，andthepositiveratewas97whichwasobviouslyhigherthanthatinnormalchil—dren(20)(P-<0．01)．Thepositiverateof14kindsofanti—milkspecific-IgGinse

6、rumofchildrenwithallergicpurpurawasthehighest，andthatofanti-eggspecific-IgGwasthesecond，andthatofanti—chickenandporkspecific-IgGwasthelowest．Afterantianaphylaxisanddiettherapy，foodspecific-IgGantibodiesobviouslydecreased(Pd0．01)．[Conclu—sion]Therearemanykindsoffoodintolerance-associatedIgGan

7、tibodiesinchildrenwithallergicpurpura．Allergenssuchasmilkandeggsarecommonlyseen．Foodmaybeoneofthereasonsofallergicpurpura．Reasonabledietarytherapyishelpfulforthetreatmentofallergicpurpura．[-Keywords~Purpura，Schoenlein—Henoch：ImmunoglobulinG[中图分类号]R