外周T细胞淋巴瘤患者外周血中髓源性抑制细胞的表达及意义.pdf

《外周T细胞淋巴瘤患者外周血中髓源性抑制细胞的表达及意义.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、282TianjinMedJ，March2015，Vo1．43No．3外周T细胞淋巴瘤患者外周血中髓源性抑制细胞的表达及意义李艳丽，卜庆摘要：目的探索外周T细胞淋巴瘤(FFCL)患者外周血中髓源性抑制细胞(MDSCs)数量与预后的关系。方法收集PTCL患者23例，选取14例同期健康体检者作为正常对照组，采用流式细胞仪检测其外周血MDSCs／单核细胞比例，分析MDSCs数量与PTCL患者预后及临床特征的关系。结果MDSCs在PTCL患者外周血单核细胞中所占的比例高于正常对照组f(4．59-+1．41

2、)％US(1．36+_0．59)％，P<0．01]。PTCL化疗后外周血MDSCs的表达(1．29±2．95)％较化疗前明显降低。结外侵犯部位、骨髓侵犯、临床分期、IPI评分不同的PTCL患者外周血MDSCs的表达差异有统计学意义(P<0．05)。结论MDSCs在PTCL患者外周血中高表达，提示与肿瘤发生及预后不良有关。关键词：淋巴瘤，T细胞，外周；流式细胞术；髓源性抑制细胞中图分类号：R733．41文献标志码：A，DOI：10．3969／j．issn．0253—9896．2015．03．016T

3、heexpressionandsignificanceofMDSCsinperipheralbloodinpatientswithperipheralTcelllymphomaLIYanli，BuQingDepartmentofMedicalOncology,theAffiliatedHospitalofGuilinMedicalUniversity,Guilin541000,ChinaCorrespondingAuthorE—mail：buqing1993@qq．comAbstract：Obje

4、ctiveTostudytherelationshipbetweenthenumberofmyeloid—derivedsuppressorcells(MDSCs)inperipheralbloodandprognosisinpatientswithperipheralT—celllymphoma(PTCL1．MethodsTwenty—threepatientswithPTCLwereselectedinthisstudyand14healthypersonswereusedasthenorma

5、lcontro1．TheproportionofMDSCs／mononu—clearinperipheralbloodwasdetectedbyflowcytometry．ThecorrelationbetweenthenumberofMDSCsandtheclinicalcharacterandprognosisinpatientswithPTCLwasanalyzed．ResultsTheproportionofMDSCsinperipheralbloodwassig-nificantlyhi

6、gherinpatientswithPTCLthanthatofhealthysubjects【(4．59~1．41)％VS(1．36-+0．59)％，P<0．01]．ThenumberofMDSCsinperipheralbloodwassignificantlydecreasedafterchemotherapycomparedwiththatbeforetreatment[(1．29±2．951％．P<0．o5)1．ThereweresignificantdifferencesinMDSCs

7、expressionsinpatientsbetweendifferentextranodalinvolve—ment，bonemarrowinvolvement，clinicalstageandIPIscore(P<0．05)．ConclusionThehigherexpressionofMDSCsmayberelatedtotheprogressioninpatientswithPTCL．Keywords：lymphoma，T—cell，peripheral；floweytometry；mye

8、loid—derivedsuppressorcells髓源性抑制细胞(myeloid—derivedsuppressor成熟(胸腺后)T细胞和自然杀伤(NK)细胞的恶性cells，MDSCs)是一群来源于骨髓祖细胞和未成熟髓肿瘤，具有侵袭性强、病情迁延、容易复发、预后不良细胞，具有免疫抑制功能的髓系细胞。MDSCs被炎等特征，目前尚无标准治疗方法，常规化疗方案如性介质从骨髓募集到外周，经过活化可以抑制机体CHOP、EPOCH等虽近期疗效尚可，但复发率仍较对肿瘤的免疫功能，使肿瘤细胞