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《外周T细胞淋巴瘤患者外周血中髓源性抑制细胞的表达及意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、282TianjinMedJ,March2015,Vo1.43No.3外周T细胞淋巴瘤患者外周血中髓源性抑制细胞的表达及意义李艳丽,卜庆摘要:目的探索外周T细胞淋巴瘤(FFCL)患者外周血中髓源性抑制细胞(MDSCs)数量与预后的关系。方法收集PTCL患者23例,选取14例同期健康体检者作为正常对照组,采用流式细胞仪检测其外周血MDSCs/单核细胞比例,分析MDSCs数量与PTCL患者预后及临床特征的关系。结果MDSCs在PTCL患者外周血单核细胞中所占的比例高于正常对照组f(4.59-+1.41
2、)%US(1.36+_0.59)%,P<0.01]。PTCL化疗后外周血MDSCs的表达(1.29±2.95)%较化疗前明显降低。结外侵犯部位、骨髓侵犯、临床分期、IPI评分不同的PTCL患者外周血MDSCs的表达差异有统计学意义(P<0.05)。结论MDSCs在PTCL患者外周血中高表达,提示与肿瘤发生及预后不良有关。关键词:淋巴瘤,T细胞,外周;流式细胞术;髓源性抑制细胞中图分类号:R733.41文献标志码:A,DOI:10.3969/j.issn.0253—9896.2015.03.016T
3、heexpressionandsignificanceofMDSCsinperipheralbloodinpatientswithperipheralTcelllymphomaLIYanli,BuQingDepartmentofMedicalOncology,theAffiliatedHospitalofGuilinMedicalUniversity,Guilin541000,ChinaCorrespondingAuthorE—mail:buqing1993@qq.comAbstract:Obje
4、ctiveTostudytherelationshipbetweenthenumberofmyeloid—derivedsuppressorcells(MDSCs)inperipheralbloodandprognosisinpatientswithperipheralT—celllymphoma(PTCL1.MethodsTwenty—threepatientswithPTCLwereselectedinthisstudyand14healthypersonswereusedasthenorma
5、lcontro1.TheproportionofMDSCs/mononu—clearinperipheralbloodwasdetectedbyflowcytometry.ThecorrelationbetweenthenumberofMDSCsandtheclinicalcharacterandprognosisinpatientswithPTCLwasanalyzed.ResultsTheproportionofMDSCsinperipheralbloodwassig-nificantlyhi
6、gherinpatientswithPTCLthanthatofhealthysubjects【(4.59~1.41)%VS(1.36-+0.59)%,P<0.01].ThenumberofMDSCsinperipheralbloodwassignificantlydecreasedafterchemotherapycomparedwiththatbeforetreatment[(1.29±2.951%.P<0.o5)1.ThereweresignificantdifferencesinMDSCs
7、expressionsinpatientsbetweendifferentextranodalinvolve—ment,bonemarrowinvolvement,clinicalstageandIPIscore(P<0.05).ConclusionThehigherexpressionofMDSCsmayberelatedtotheprogressioninpatientswithPTCL.Keywords:lymphoma,T—cell,peripheral;floweytometry;mye
8、loid—derivedsuppressorcells髓源性抑制细胞(myeloid—derivedsuppressor成熟(胸腺后)T细胞和自然杀伤(NK)细胞的恶性cells,MDSCs)是一群来源于骨髓祖细胞和未成熟髓肿瘤,具有侵袭性强、病情迁延、容易复发、预后不良细胞,具有免疫抑制功能的髓系细胞。MDSCs被炎等特征,目前尚无标准治疗方法,常规化疗方案如性介质从骨髓募集到外周,经过活化可以抑制机体CHOP、EPOCH等虽近期疗效尚可,但复发率仍较对肿瘤的免疫功能,使肿瘤细胞
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