高糖对人视网膜色素上皮细胞神经钙黏连蛋白和纤维连接蛋白表达的影响-论文.pdf

《高糖对人视网膜色素上皮细胞神经钙黏连蛋白和纤维连接蛋白表达的影响-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、国际眼科杂志2014年9月第14卷第9期www．ies．net．cn电话：029—8224517282210956电子信箱：IJO．2000@163．tom·实验论著·___I-__口糖对人视网膜色素上皮细胞神经钙黏连蛋白和纤维连I'mJ接蛋白表达的影响毕文娇，李睿妹，侯定善，范妍，张晓梅作者单位：(150001)中国黑龙江省哈尔滨市，哈尔滨医科大学thedifferencesbetweenthecontrolgroupandthehigh附属第一医院眼科glucosegroup(48and72h)weresignificantrespectively作者简介：毕文娇，在读硕士研究生

2、，研究方向：眼底病的发病及(P<0．05)．Meanwhile，theexpressionoffibronectin防治。mRNAinRPEcellswasincreasedinhighglucosegroupat通讯作者：张晓梅，医学博士，博士研究生导师，教授，主任医师，24h。andreachedthepeakat72h(F=50．543，尸=0．000)．研究方向：眼底病的发病及防治．zhangxm667@163．conTherewerenosignificantdi仟erencesbetweenthecontroI收稿日期：2014—04—22修回日期：2014-07-29g

3、roupandthehighglucosegroupat24h．ComparedwiththecontroIgroup．theexpressionoffibronectinmRNAinHighglucoseontheexpressionofN--hRPEcellswasincreasedsignificantlyinhighglucosegroup(48and72h)respectively(P=0．000，尸=0．000)．cadherinandfibronectininretinalpigment·coNCLUSlON：Theexpressionofepitheliummarke

4、rN—epitheliumcellscadherinisdown—regulatedunderhighglucoseconditionsinhRPEcellsinvitro．MeanwhiIe，theWen-JiaoBi，Rui—ShuLi，Ding—ShanHou，YanexpressionofmesenchymalmakerfibronectinisinducedFan，Xiao-MeiZhangandappearedtoEMTchanges．Resultsofthisstudywillenrichourgrowingunderstandinginproliferativedia

5、beticDepartmentofOphthalmology．theFirstAffiliatedHospitalofHarbinretinopathyandhopefullyleadtonovelinsightsfortheMedicalUniversity，Harbin150001，HeilongjiangProvince，Chinapathogenesisandtherapeutictreatments．Correspondenceto：Xiao-MeiZhang．DepartmentofOpt,thalmology，·KEYWORDS：humanretinalpigmente

6、pithelialcell；hightheFirstAffiliatedHospitalofHarbinMedicalUniversity，Harbinglucose；epithelial—mesenchyaltransition；N—150001，HeilongjiangProvince，China．zhangxm667@163．corncadherin；fibronectinReceived：2014一O4—22Accepted：2014—07—29Citation：BiWJ，LiRS，HouDS，eta1．HighglucoseontheAbstractexpressionof

7、N-cadherinandfibroneetininretinalpigmentepithelium·AIM：ToobservetheexpressionofN—cadherinandcells．GuojiYankeZazhi(IntEyeSci)2014；14(9)：1578-1583fibronectininretinalpigmentepithelium(RPE)cellsinvitrounderhighglucoseconditions，furth