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时间:2020-05-15
《甲泼尼龙鼓室内注射与全身应用在分型治疗特发性突发性聋的疗效分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、宁夏医学杂志2014年1O月第36卷第l0期NingxiaMedJ,Oct.2014,Vol36,No.10Doi:10.13621/j.1001—5949.2014.10.0910·临床研究·甲泼尼龙鼓室内注射与全身应用在分型治疗特发性突发性聋的疗效分析杨敬,中学良,侯丽,郭宏庆,马瑞霞。[摘要]目的观察甲泼尼龙鼓室内注射与全身应用治疗不同分型特发性突发性感音神经性聋(ISSHL)的疗效。方法选取单耳特发性突聋患者167例,其中低中频下降型47例,中高频下降型42例,平坦型15例,全聋型63例。各型均采用随机数字表法分为2组,即全
2、身给药组(84耳),鼓室给药组(83耳),对各型患者有效率及治愈率分组进行分析。结果鼓室内注射组低中频下降型治愈率较中高频下降型、全聋型高(P<0.05),鼓室内注射组低中频下降型治愈率较对照组高(P<0.05),其余三型问差异无统计学意义。结论低中频下降型ISSHL经鼓室内注射甲泼尼龙治疗比全身性给药效果更佳,其它三型如患者无激素应用禁忌建议首选全身用药。[关键词]特发性突发性感音神经性聋;鼓室内注射;甲泼尼龙[中图分类号]R765[文献标识码]AIntratympanicinjectionandsystemicofmethylp
3、rednis0l0neintreatmentofidiopathicsuddenhearinglossbytypeYANGring。,SHENXuelianf,HOULi,GUOHongqin,MARuixia.1.NingxiaMedicalUniversity,Yinchuan750004,China;2.De—partmentofORL—HNS,GeneralHospitalofNingxiaMedicalUniversity,Yinchuan750004,ChinaCorrespondingauthor:MARuixia,E
4、mail:maruixia4368@sina.corn[Abstract]ObjectiveToassessthetherapeuticeffectofintratympanieinjectionandsystemicofmethy1prednisoloneintreat—mentoftypingidiopathicsuddensensorineuralhearingloss(ISSNHL).Methods167patientswithISSNHL,including47withheatinglossinlow—middlefreq
5、uencies,42inmiddle—highfrequencies,15inallfrequenciesand63intotaldeafness,wererandomlydividedintotwogroups:thesystemicdruggroup(84ears)andintratympanicinjectiongroup(83ears).ResultsInintratympanicinjectiongroup,therecoveryrateinlow—middlefrequenciessubgroupswassignific
6、anthigherthanthatinmiddle—high(P<0.05)andallfre—quenciessubgroups(P<0.05).Thepatientsoflow—middlefrequencieswithintratympanicinjectionofmethylprednisolonewassignifi—canthigherthansystemicapplication(P<0.05),andtherewerenostatisticalsignificancesinotherthreetypinggroups
7、byintratympanicinjectionofmethy1prednisolonewhencomparedwithsystemicapplication.ConclusionIntratympanicinjectionshouldbeoptimizationforlow—middlefrequencytypeISSHL.Ifpatientswereglucoeortieoids—freeapplications.systemicapplicationshouldbeappliedforoth—erthreetypingfreq
8、uencies.[Keywords]Idiopathicsensorineuralsuddenhearingloss;Transtympanic;Methylprednisolone特发性突发性感音神经性聋(ISSHL),即没有明男9
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