廖志峰应用健脾补肾活血汤治疗慢性再生障碍性贫血临床观察.pdf

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1、而部．jr廛2年第27卷第J期彦志峰应用健脾肾活血汤治幔牲再生障碍牲贫血临床观察廖挺，刘则鹏z，张丽娜1甘肃省中医院，甘肃兰州73005O；2甘肃中医学院[摘要]目的：观察健脾补肾活血汤治疗l慢性再生障碍性贫血(再障)的临床疗效。方法：将再障患者80例随机分为对照组、治疗组各40例。对照组采用司坦唑醇片联合环孢素A(CsA)治疗，治疗组在对照组基础上加用健脾补肾活血汤治疗，疗程6个月。观察2组患者f临床疗效及治疗前后外周血T细胞亚群、外周血象、血清肿瘤坏死因子(TNF一)和白介素3(IL-3)的变化情况结果：治疗组治疗后CD4升高、CD8降低、C

2、D4／CD8升高；TNF—降低，IL一3升高，与治疗前及对照组比较差异均有统计学意义(P<0．05)。结论：健脾补肾活血汤可能通过改善T淋巴细胞亚群的比例，减少TNF一造血负调控因子及增加IL一3造血正调控因子的释放，解除对骨髓造血的抑制，从而促进造血功能的恢复。[关键词]再生障碍性贫血，慢性；T淋巴细胞亚群；肿瘤坏死因子；白介素一3；健脾补肾活血汤[中图分类号]R556．5[文献标识码]A[文章编号]1004-6852(2014)1卜0053-03ClinicalObservationonLiaoZhngApplyingJianPiBuShen

3、HuoXueDecoctiontoChronicAplasticAnemiaL／A0孔，LIUZepe，ZHANGLinaJGansuProvincialHospitalofTraditionalChineseMedicine，Lanzhou730054China,2GansuUniversityofTraditionalChineseMedicine^bstract0bjecfive：ToobservecurativeeffectsofJianPiBuShenHuoXuedecoctionintreatingchronicaplasticane

4、mia(CAA)．Methods：Eightypatientswererandomizedintothecontrolgroupandthetreatmentgroup．ThecontrolgroupweretreatedbystanozololtabletsandciclosporinA(CsA)，andthetreatmentgroupJianPiBuShenHuoXuedecoctiononthefoundationofthetherapygiventothecontrolgroup，onecourseofthetreatmentwassi

5、xmonths．Therapeuticefects，thechangesofT—lymphocytesubsets，peripheralblood，tunlornecrosisfactor-a(TNF—)andinterleukin一3(IL一3)inbothgroupswereobserved．Results：CD4wasraised，CD8decreased，CD4／CD8increased；TNF-OdloweredbutIL一3raised，thediferencesweresignificantwhenthetreatmentgroup

6、aftertreatingwascomparedwithbeforetreatingorthecontrolgroupfP<0．05)．Conclusion：JianPiBuShenHuoXuedecoctioncouldpromotetherecoveryofhemopoiesis，whichmightberealizedbyimprovingtheratioofT-lymphocytesub—sets，reducingthereleaseofnegativeregulatingfactorTNF-OL，increasingpositivere

7、gulatingfactorIL-3andelimi-natingtheinhibitionofbonema~owhemopoiesis．Kolnmrdschronicaplasticanemia；T·lymphocytesubsets；tumornecrosisfactor；interleukin一3：J／an／~BuShenHuoXuedecoction再生障碍性贫血(AA)是非骨髓浸润和网硬蛋廖志峰主任医师健脾补肾活血法联合司坦唑醇白增加引起的骨髓造血干细胞减少所导致的全血片、环孢素A(CsA)治疗再障40例，取得满意疗效，细胞减。AA有急

8、性、慢性之分，急性再障(AAA)现报道如下：发病急，以感染、出血症状为主；慢性再障(再障)l资料与方法发病缓慢，以贫血多见，感染及出血症