抗组胺耐药慢性荨麻疹患者甲状腺自身抗体检测结果分析.pdf

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1、HainanMedJ，Jtd．2015，Voi．26，No．14海南医学2015年7B第26卷第l4期doi：10．3969／j．issn．1003—6350．2015．14．0749·论著·抗组胺耐药慢性荨麻疹患者甲状腺自身抗体检测结果分析黄珍，刘万红，侯占英(深圳市龙华新区中心医院皮肤科，广东深圳5181lO)【摘要】目的分析抗组胺耐药慢性荨麻疹患者的甲状腺自身抗体及甲状腺激素水平变化与意义。方法选取抗组胺耐药慢性荨麻疹患者40例为观察组，同期在我院做体检的健康者4O例为对照组，检测两组受试者的甲状腺自身抗体和甲状腺各项功能指标，并进行

2、自体血清皮肤试验(ASST)。结果观察组的促甲状腺素受体抗体(TRAb)、抗甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)等甲状腺自身抗体指标及ASST的阳性率明显高于对照组，差异均有统计学意义(P

3、得临床深入研究。【关键词】自身免疫；自身抗体；慢性荨麻疹【中图分类号】R758．24【文献标识码】A【文章编号】1003---6350(2015)l4—2075—O3Analysisofthyroidautoantibodiesdetectioninpatients、】lrithantihistamine-resistantchronicurticaria．HUANCZhen，LIUWan—hong,HOUZhan-ying．DepartmentofDermatology,ShenzhenLonghuaNewDistrictCentralH

4、ospital,Shenzhen518110,Guangdong,CHINA【Abstract】ObjectiveToanalyzethechangesandsignificanceofthyroidautoantibodiesandthyroidhormonelevelsinpafien~withantihistamine-resistantchronicurticaria．MethodsFortypatientswithantihistamine．resistantchronicurticariawereselectedasthestu

5、dygroup，and40healthypersonswereselectedasthecontrolgroup．Thethyroidautoantibodies【thyrotropinreceptorantibody(TRAb)，thyroidperoxidaseantibody(TPOAb)，thyroglobulinantibody(TGAb)】intwogroupsweredetected，andautologousserumskintest(ASST)wasperformed．Thyroidfunctionindexesofthe

6、twogroupsweredetected．ResultsTRAb，TPOAb，TGAblevelsandthepositiverateofASSTinthestI1dygroupweresignificantlyhigherthanthoseinthecontrolgroup．Thedifferenceswereofstatisticalsignificancef尸

7、totaltriiodothyro-nine(TT3)，highsensitivethyroidstimulatinghormone(TSH)andotherindicatorsinthestudygroupweresignificant—lyhigherthanthoseinthecontrolgroup，andthediferenceswereofstatisticalsignificance(P<0．05)．ConclusionInpatientswithantihistamine—resistantchronicurticaria，

8、thyroiddiseaseisofcloserelationshipwiththyroidautoantibod．ies，andsenlmappearsankindsofaut