灌注栓塞联合微波治疗原发性肝癌效果观察.pdf

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1、肝脏病杂志2015年5月第l8卷箜期』堡!·241··肝癌·灌注栓塞联合微波治疗原发性肝癌效果观察白卫兵，王建睿【摘要】目的探讨灌注栓塞联合微波治疗原发性肝癌的效果与机制。方法原发性肝癌患者120例，对照组(60例)给予常规灌注栓塞治疗，治疗g]t(60例)在对照组治疗的基础上联合微波治疗，疗程4个周期；治疗结束后，观察两组有效性、肝功能、免疫细胞和并发症情况。结果治疗组与对照组的总有效率分别为80．O％与50．0％，治疗期间两组的并发症多为恶心呕吐、疼痛、发热、肝功能不全等，治疗组的并发症发生情况明显低

2、于对照组，两组差异均有统计学意义(P<0．05)；治疗结束时，治疗组和对照组NK细胞分别为(17．994-6．44)％和(18．094-6．30)％，CD4'·CD25q'reg为(4．4±2．11)％和(7．30±3．09)％，后者在两组间差异有统计学意义(P<0．05)；治疗组和对照组AST分别为(41．994-16．4)U／L和(78．094-16．30)U／L，ALT分别为(40．44±12．11)U／L和76．304-13．09)，二者在两组间差异均有统计学意义(P<0．05o结论灌注栓塞联合微

3、波治疗原发性肝癌能有效提高抗瘤效果与恢复肝功能，降低并发症的发生，其作用与降低调节性T细胞活性有关。【关键词】原发性肝癌；微波；灌注栓塞；调节性T细胞DOI：10．39696．issn．1672-5069．2015．02．006~fHcacyofperfusionembolizationcombinedwithmicrowaveinpatientswitlIprimaryfivercancerBa／Weibing，WangJianrui．DepartmentofGeneralSurgery，TheFour

4、thPeopleHospitalofYulinC，Yulin719000，ShaanxiProvince，Chbza【Abstract】0bjectiveToexploretheeficacyandmechanismofperfusionembolizationcombinedwithmi-crowaveinpatientswithprimarylivercancer．Methods120caseswithprimarylivercancerwererecruited,．Pa—tientsinthecon

5、trolgroup(n=60)weretreatedwithconventionalperfusionembolism，andpatientsinthetreat—mentgroup(n=60)weregivenperfusionembolismcombinedwithmicrowaveforfourcycles．Treatmenteficacy，liv—erfunction，immunecellcountsandcomplicationwereobserved．ResultsTheefectiverat

6、eoftreatmentgroupandcontrolgroupwere8O．0％and50．O％respectively．Thecomplicationswhichoccurredinbothgroupsduringthetreatmentincludednausea，vomiting，pain，feverandhypohepatia，however，thecomplicationincidenceofthetreatmentgroupwassignificantlylowerthanthatofthe

7、controlgroup(P

8、lgroup(7．30+3．O9)％，P