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时间:2020-05-09
《标准化^131I治疗与ATD治疗Grave’s甲亢疗效比较.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·866·浙江临床医学2014年6月第l6卷第6期标准化lI治疗与ATD治疗Grave’s甲亢疗效比较王春梅王雪梅★黄甫建王城张国建【摘要】目的比较标准化”I治疗与抗甲状腺药物(antithyroiddrugs,ATD)治疗Grave’s甲亢的疗效;比较标准化I治疗后不同时间段的疗效;比较标准化”I治疗对老年人与中青年人Grave’s甲亢的疗效。方法标准化”1治疗组:停用影响甲状腺摄取”I的食物如海带、紫菜、海鱼等和药物如他巴唑、丙基硫氧嘧啶、复方碘溶液、胺碘酮等,”I治疗前进行常规检查,甲状腺最高吸”I率测定、有效半衰期测定,甲状腺图像采集与重
2、量测定,治疗剂量确定。I空腹一次t:JH~。ATD治疗组:治疗前常规检查、治疗剂量确定。结果(1)标准化I治疗组痊愈率62.6%、好转率13.3%、甲减率19.5%、复发率4.6%,ATD治疗组痊愈率39.5%、好转率10.8%、甲减率3.1%、复发率46.6%,标准化”I治疗组较ATD治疗组疗效明显提高(P<0.05)。(2)标准化”I治疗后随着观测时间的延长,痊愈率逐渐上升,甲减发生率逐渐上升。(3)标准化”I治疗,中青年组痊愈率高于老年组,甲减发生率低于老年组,差异均有统计学意义(P<0.05)。结论标准化”I治疗Grave’s甲亢疗效优于
3、ATD治疗,且较安全、经济,是一种较为理想的Grave’s甲亢治疗方法。【关键词】标准化1311治疗ATD治疗Grave’s甲亢甲状腺功能减低【Abstract】Objective(1)EvaluatingtheeficacyofGrave’sdiseasewith”Icomparingtoantithyroiddrugs(ATD).(2)ObservingtheeficacyofGrave’sdiseaseinadiferentperiodafterthetreatmentwithI.(3)Observingthediferenteficacy
4、ofGrave’sdiseasebetweenoldpatientsandthemiddleaged—youngpatients.Methods(1)WereviewedtherecordsfrompatientswithGraves’diseaseattheAfiliatedHospitalofInnerMongoliaMedicalUniversity,betweenJanuary2007andSeptember2010.AllofthepatientsdividedintoIgroupandATDgroup.Everygroupconsis
5、ted195patients.PatientsinIgroupwereranginginagefrom18to76years(mean42.93±13.68),men60,women135,thecourseofGraves’disease2.10±1.16.PatientsinATDgroupwereranginginagefrom17to72years(mean39.674-13.92),men65,women130,thecourseofGraves’disease1.984-1.08.(2)AllpatientsinIgroupstopp
6、edeatingthosefoods(seaweed,laver,seafish,ect)anddrugs(methimazole,propylthiouracil,liquoriodicompostus,amiodarone,ect),performedtheseexamination(radioiodineuptake,thyroideffectivehalf-life(EHL),estimatedthyroidweightbeforetreatment,administratedIdose,takedIforpatients,followe
7、darrangement,andanalyzedtheeficacyof”Itreatment.AllpatientsinATDgroupperformedroutineexaminationsbeforeATDtreatment,administratATDdose,followedarangement,andanalyzedtheeficacyofATDtreatment.Results(1)Therecoveryratein“Igroupwas62.6%.theremissionrate13.3%,thehypothyroidismrate
8、19.5%,andtherelapserate4.6%.TherecoveryrateinATDgroupwas39.5%.therem
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