癌基质变化与前列腺癌去势治疗抵抗的临床相关性研究.pdf

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1、AsianJournalofAndrology(2014)16。710-714@2014AJASIMM＆SJTUAllrightsreserved1008—682Xwwwasiaandrocom；wwwajandrology．com墨拶萋黧OpenAccessORIGINALARTICLEIntensityofstromalchangesisassociatedwithtumorrelapseinclinicallyadvancedprostatecanceraercastrationtherapyJian-PingWu，Wen—BinH

2、uang，HuiZhou，Lu—WeiXu，Jian—HuaZhao，Jia—GenZhu，Jiang—HaoSu，Hong—BinSunReactivestromalchangesinprostatecancer(PCa)arelikelyinvolvedintheemergenceofcastration．resistantPCa(CRPC)．ThisstudywasdesignedtoinvestigatestromaIchangesinpatientswithclinicallyadvancedPeaandanalyzetheir

3、prognosticsignificance．Prostateneedlebiopsiesobtainedfrom148patientsbeforecastrationtherapywereanalyzedbyMassontrichromestainingandimmunohistochemicaIanalysisofvimentinanddesmin．ReactivestromagradingwasinverselycorrelatedwithGleasonscore．Stromagrade(Massonstain82．8％vs45．6

4、％，P<0．O01)andvimentinexpression(P=0．005)weresignificantlyhigher．anddesminexpression(P=0．004)significantlyIower,inreactivestromaoftumorswithaGleasonscoreof6—7thaninadjacentperitumoraltissue．Kaplan-Meieranalysisshowedasignificantassociationbetweenreactivestromagradeintumors

5、andtheoccurrenceofCRPCinpatientswithaGleasonscoreof6—7(P=0．009)．Furthermore。patientswithhighervimentinorIowerdesminexpressionhadashorterdisease-freeperiod．Inmultivariateanalysis．onlyvimentinexpressionwasasignificantpredictoroftumorrelapse(hazardratio1．78，95％confidenceinte

6、rvaI1．12—10．26。P=0．012)Thesefindingsindicatethattheintensityofreactivestromaisassociatedwithcastrationresponsiveness．especiallyinpatientswithalowerGleasonscorewheretheabundantstromacomponentismostfrequentlyfound．Highexpressionofvimentinintumorstromawasindependentlyassocia

7、tedwithpooroutcomesinpatientswithGleasonscoresof6—7，andmayserveasanewprognosticmarkerindailypractice．s『a，7Journa／ofAndrology(2014)16．71O一714；doi：1O．4103／1008—682X．129131：publishedonliBe：20May2014Keywords：cancer-associatedfibroblasts；castrationresistance；prostatecancer；rea

8、ctivestroma；vimentinINTR0DUCTl0NCastration—inducedinvolutionofnormalprostateglandswasfoundProsta