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时间:2020-05-09
《癌基质变化与前列腺癌去势治疗抵抗的临床相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、AsianJournalofAndrology(2014)16。710-714@2014AJASIMM&SJTUAllrightsreserved1008—682Xwwwasiaandrocom;wwwajandrology.com墨拶萋黧OpenAccessORIGINALARTICLEIntensityofstromalchangesisassociatedwithtumorrelapseinclinicallyadvancedprostatecanceraercastrationtherapyJian-PingWu,Wen—BinH
2、uang,HuiZhou,Lu—WeiXu,Jian—HuaZhao,Jia—GenZhu,Jiang—HaoSu,Hong—BinSunReactivestromalchangesinprostatecancer(PCa)arelikelyinvolvedintheemergenceofcastration.resistantPCa(CRPC).ThisstudywasdesignedtoinvestigatestromaIchangesinpatientswithclinicallyadvancedPeaandanalyzetheir
3、prognosticsignificance.Prostateneedlebiopsiesobtainedfrom148patientsbeforecastrationtherapywereanalyzedbyMassontrichromestainingandimmunohistochemicaIanalysisofvimentinanddesmin.ReactivestromagradingwasinverselycorrelatedwithGleasonscore.Stromagrade(Massonstain82.8%vs45.6
4、%,P<0.O01)andvimentinexpression(P=0.005)weresignificantlyhigher.anddesminexpression(P=0.004)significantlyIower,inreactivestromaoftumorswithaGleasonscoreof6—7thaninadjacentperitumoraltissue.Kaplan-Meieranalysisshowedasignificantassociationbetweenreactivestromagradeintumors
5、andtheoccurrenceofCRPCinpatientswithaGleasonscoreof6—7(P=0.009).Furthermore。patientswithhighervimentinorIowerdesminexpressionhadashorterdisease-freeperiod.Inmultivariateanalysis.onlyvimentinexpressionwasasignificantpredictoroftumorrelapse(hazardratio1.78,95%confidenceinte
6、rvaI1.12—10.26。P=0.012)Thesefindingsindicatethattheintensityofreactivestromaisassociatedwithcastrationresponsiveness.especiallyinpatientswithalowerGleasonscorewheretheabundantstromacomponentismostfrequentlyfound.Highexpressionofvimentinintumorstromawasindependentlyassocia
7、tedwithpooroutcomesinpatientswithGleasonscoresof6—7,andmayserveasanewprognosticmarkerindailypractice.s『a,7Journa/ofAndrology(2014)16.71O一714;doi:1O.4103/1008—682X.129131:publishedonliBe:20May2014Keywords:cancer-associatedfibroblasts;castrationresistance;prostatecancer;rea
8、ctivestroma;vimentinINTR0DUCTl0NCastration—inducedinvolutionofnormalprostateglandswasfoundProsta
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