尿激酶与低分子肝素钙联用治疗急性心肌梗死临床研究-论文.pdf

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1、临春医学工程2013年9月第20卷第9期·l125··论著·盏床研究)尿激酶与低分子肝素钙联用治疗急性心肌梗死临床研究鼋(湖南省溆浦智德医院心血管内科，湖南怀化419323)【摘要】目的观察尿激酶与低分子肝素钙联用治疗急性心肌梗死的-临床疗效。方法选取我院从2002年1月至2012年12月所收治的120例急性心肌梗死患者作为临床研究对象，并将所有患者随机分为治疗纽和对照纽两组各6o例。两纽均进行严密心电检查、吸氧、绝对卧床休息、硝酸酯类药物、ACEI药物和服用肠溶阿司匹林等，治疗组在此基础上加用尿激酶和低分子肝素钙进行治疗

2、。观察两组患者的急性期心脏事件发生情况和冠状动脉再通情况，以综合考察两组疗效。结果两组患者在梗死后心绞痛、心力衰竭和死亡率的差异均有统计学意义，治疗组显著低于对照组(尸<0．05)。治疗组冠状动脉再通率为63．3％，对照组冠状动脉再通率为26．7％，两组冠状动脉再通率比较，差异有统计学意义(尸

3、／j．issn．1674—4659．2013．09．1125ClinicalResearchofUrokinaseCombinedwithLow-Molecular—WeightHeparinintheTreatmentofAcuteMyocardialInfarctionTANGZhongping(CardiovascularDepartment，ZhideHospitalofXupuCounty，Huaihua419323，China)[Abstract】ObjectiveToobservetheclinicaleff

4、ectofurokinasecombinedwithlow—molecular—weiglatheparininthetreatmentofacutemyocardialinfarction．Methods120patientswithacutemyocardialinfarctioninourhospitalfromJanuary2002toDecember2012wereselectedandrandomlydividedintothetreatmentgroupandcontrolgroup，with60casesi

5、neachgroup．AllpatientsreceivedtheECGexamination，oxygen，absolutebedrest，anddrugswithnitrates，ACEIandenteric—coatedaspirin，andpatientsinthetreatmentgroupreceivedtheextracombinationtreatmentwithurokinaseandlow—molecular·weightheparin．Thecardiaceventsandcoronaryartery

6、recanalizationoftwogroupswereobservedtoevaluatetheclinicaltreatmentefect．ResultsThetreatmentgrouphadlowerpostinfarctionalanginapectorisevents，heartfailureeventsandmortalitycomparedwiththecontrolgroup，andthedifferenceswerestatisticallysignificant<0．05)．Thecoronarya

7、rteryrecanalizationratewas63．3％inthetreatmentgroupand26．7％inthecontrolgroup，andthediferenceswerestatisticallysignificant(P

8、provepatients’survivalrateandqualityoflife，whichisworthyofclinicalapplicationandpromotion．【Keywords]Urokinase；Low—molecular—weightheparin；Acutemyocardia