欢迎来到天天文库
浏览记录
ID:55057908
大小:206.81 KB
页数:3页
时间:2020-05-08
《多烯磷脂酰胆碱联合还原型谷胱甘肽治疗慢性乙型肝炎肝纤维化临床研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、泰山医学院学报JOURNALOFTAISHANMEDICALCOUlJEGEVo1.34No.112013847多烯磷脂酰胆碱联合还原型谷胱甘肽治疗慢性乙型肝炎肝纤维化临床研究刁凌云王胜英(徐州市中医院,江苏徐州221000)摘要:目的评价多烯磷脂酰胆碱联合还原型谷胱甘肽治疗慢性乙型肝炎肝纤维化的疗效。方法120例慢性乙型肝炎肝纤维化患者随机分为两组:治疗组应用多烯磷脂酰胆碱465mg+还原型谷胱甘肽1.8g静滴1次/天;对照组应用苦参素0.6g静滴1次/天,两组疗程均为8周。观察用药前后血清肝纤维化(HA、LN、PC-Ⅲ、IV-C)的变化。结果治疗后两组患者血清肝纤维化
2、各项指标均明显改善(P<0.05),与对照组比较差异有统计学意义(P3、hepaticfibrosiscausedbyhepatitisBDIAO血ng—yunWANGSheng-y/ng(AfiliatedXuzhouTCMHospitalofNanjingUniversityofTraditionalChineseMedicine,Xuzhou221000,China)Abstract:Objective:Toinvestigatetheclinicaleficacyofcombinationtreatmentofpolyeneph0sphatidylch0linetom-binedwithreducedglutathioneinpati4、entswithhepa~cfibrosiscausedbyhepatitisB.Methods:Onehundredandtwentypa-tientswithhepaticfibrosisofhepatitisBvirusinfectionwererandomlydividedintotWOgroups.Thetreatmentgroup(60pa-tients)wasgivenpolyenephosphatidykh0ljne465mgdaily,reducedglutathione1.8gdailybyintravenousfor8weeks;thecontrol5、group(60patients)wasgivenoxymatrine0.6gdailybyintravenousfor8weeks;Theserumhyaluronicacid(HA),serumprocollagentypelII(PC-III),laminin(LN)andIVconagen(IV—C)Wereobserved.Results:Theserumfibrosismarkersweredecreasedintwogroupsaftertreatment(P<0.05),andthetreatmentgroupdecreasedsignificantlyc6、omparedwithcontrolgroup(P<0.05).Conclusion:PolyenephosphatidyleholineandreducedglutathioneCaneffectivelyreducethelevelofhepmiefibrosismarksinchronichepatitisBpatients.Keywords:polyenephosphatidylcholine;reducedglutathione;chronichepatitisB;liverfibrosis肝纤维化是慢性肝炎向肝硬化发展的必经阶展对改善患者预后有重要的临床价值。7、本研究对应段,三者之间无明显的界限,部分慢性乙型肝炎携带用多烯磷脂酰胆碱联合还原型谷胱甘肽治疗慢性乙者,在慢性肝炎的不同阶段均存在不同程度的肝纤型肝炎肝纤维化与苦参素组对比观察疗效。维化。因此早期抑制肝纤维化,延缓肝纤维化的进作者简介:刁凌云(1980一),男,江苏徐州人,主治医师,硕士,主要从事慢性病毒性肝炎、肝纤维化的诊治工作。泰山医学院学报JOURNALOFTAISHANMEDICALCOLLEGEV01.34No.1l2013情轻重等方面无统计学差异。1资料与方法1.2治疗方法治疗组应用多烯磷脂酰胆碱4651.1病例选
3、hepaticfibrosiscausedbyhepatitisBDIAO血ng—yunWANGSheng-y/ng(AfiliatedXuzhouTCMHospitalofNanjingUniversityofTraditionalChineseMedicine,Xuzhou221000,China)Abstract:Objective:Toinvestigatetheclinicaleficacyofcombinationtreatmentofpolyeneph0sphatidylch0linetom-binedwithreducedglutathioneinpati
4、entswithhepa~cfibrosiscausedbyhepatitisB.Methods:Onehundredandtwentypa-tientswithhepaticfibrosisofhepatitisBvirusinfectionwererandomlydividedintotWOgroups.Thetreatmentgroup(60pa-tients)wasgivenpolyenephosphatidykh0ljne465mgdaily,reducedglutathione1.8gdailybyintravenousfor8weeks;thecontrol
5、group(60patients)wasgivenoxymatrine0.6gdailybyintravenousfor8weeks;Theserumhyaluronicacid(HA),serumprocollagentypelII(PC-III),laminin(LN)andIVconagen(IV—C)Wereobserved.Results:Theserumfibrosismarkersweredecreasedintwogroupsaftertreatment(P<0.05),andthetreatmentgroupdecreasedsignificantlyc
6、omparedwithcontrolgroup(P<0.05).Conclusion:PolyenephosphatidyleholineandreducedglutathioneCaneffectivelyreducethelevelofhepmiefibrosismarksinchronichepatitisBpatients.Keywords:polyenephosphatidylcholine;reducedglutathione;chronichepatitisB;liverfibrosis肝纤维化是慢性肝炎向肝硬化发展的必经阶展对改善患者预后有重要的临床价值。
7、本研究对应段,三者之间无明显的界限,部分慢性乙型肝炎携带用多烯磷脂酰胆碱联合还原型谷胱甘肽治疗慢性乙者,在慢性肝炎的不同阶段均存在不同程度的肝纤型肝炎肝纤维化与苦参素组对比观察疗效。维化。因此早期抑制肝纤维化,延缓肝纤维化的进作者简介:刁凌云(1980一),男,江苏徐州人,主治医师,硕士,主要从事慢性病毒性肝炎、肝纤维化的诊治工作。泰山医学院学报JOURNALOFTAISHANMEDICALCOLLEGEV01.34No.1l2013情轻重等方面无统计学差异。1资料与方法1.2治疗方法治疗组应用多烯磷脂酰胆碱4651.1病例选
此文档下载收益归作者所有