同型半胱氨酸联合D-二聚体对肝癌血栓前状态监测的研究-论文.pdf

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1、·2952·检验医学与临床2013年11月第1O卷第22期LabMedClin，Novermber2013，Vo1．11，No．22·论著·同型半胱氨酸联合D一二聚体对肝癌血栓前状态监测的研究陈浩宇，钟远红，吴晓蔓，嘉红云△(广州医科大学附属第二医院检验科，广州510260)【摘要】目的探讨联合应用同型半胱氨酸(HCY)和D--：聚体(D-Dimer)对肝癌血栓前状态预测的临床应用价值。方法选取5O例原发性肝癌患者(肝癌组)，30例肝硬化患者(肝硬化组)，30例健康对照组，检测血清HCY、血浆D-Dimer的水平，应用ROc曲线分析其对肝癌血栓前状态的预测

2、价值。结果肝癌组与肝硬化组、健康对照组比较，血清HcY、D-Dimer水平均明显升高(P

3、率。【关键词】原发性肝癌；同型半胱氨酸；【)I二聚体；血栓前状态；受试者工作特征曲线DOI：10．3969／j．issn．1672—9455．2013．22．007文献标志码：A文章编号：1672-9455(2013)22—2952—02StudyofHCYcombinedwithD-DimeronmonitoringofprethromboticstateinhepatocarcinomapatientsCHENHao—yu，ZHONGYuan-hong，WUXiao—man，JIAHong—yun(DepartmentofClinicalLaborat

4、ory，theSecondAf—filiatedHospitalofGuangzhouMedicalUniversity，Guangzhou，Guangdong510260，China)[Abstract]ObjectiveToexplorethepredictivevalueofhomocysteine(HCY)combinedwithD-Dimerintheprethromboticstateofprimaryhepatocarcinoma(PHC)．Methods50casesofprimarylivercancer，30casesofhepat—i

5、csclerosisand30casesofhealthyhumanwereselected，andthelevelsofHCYandD-Dimerweredetected．Thepre—dictivevaluewasevaluatedbyROCcurve．ResultsTheHCYandD-DimerinthePHCgroupweresignificantlyhigherthanthatinhepaticsclerosisandcontrolgroup(P％0．05)．TheD-Dimerlevelwassignificantlyhigherinhe—p

6、aticsclerosisgroupthanthatinhealthyhuman(P~0．05)，whiletherewasnosignificanceofHCYbetweenthehepaticsclerosisandthecontrolgroup(P=0．912)．TheareasunderROCcurveofHCY，D-Dimerandthejointdetec—tionofthetwoindexeswere0．902，0．846and0．941，respectively．TheclinicalpredictivecriticalpointsofHC

7、YandD-DimerinPHCwithprethromboticstatewere13．28／~mol／Iand1451ng／mL，respectively．ConclusionThecorn—binationoftheHCYandD-Dimercouldpredicttheprethromboticstateoftheprimaryhepatocarcinoma．[Keywords]primaryhepatocarcinoma；HCY；D-Dimer；prethromboticstate；ROC血栓形成是恶性肿瘤的并发症之一，血栓前状态或称血栓例，女1

8、3例，年龄(58．3±5．7)岁。研究对象均排除下肢静脉前期是指机