DLE和SLE患者血清中抗RPLP0抗体水平及临床意义-论文.pdf

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1、2588实用医学杂志2014年第30卷第16期DLE和SLE患者血清中抗RPLP0抗体水平及临床意义杜艳瑜谭国珍叶瑞心陈娇霞摘要目的：了解盘状红斑狼疮(DLE)和系统性红癍狼疮(SLE)抗RPLP0抗体的表达水平，分析其与各临床表现和实验室指标的关系。方法：酶联免疫吸附法(ELISA)检测抗RPLP0抗体；直接免疫荧光(DIF)检测皮损部位的免疫复合物；常规方法检测自身抗体及补体。结果：健康对照组、DLE组、SLE组的抗RPLP0．IgG抗体的吸光度(A．U．)均值分别为：0．72±0．16，0．53±0

2、．18和1．23-I-0．62。DLE组患者的抗RPLP0．IgG抗体与健康对照组相比差异无统计学意义(P>0．05)，而SLE组高于DLE组和健康对照组(P0．05)。结论：DLE患者与健康人血清抗RPLP0抗体水平无差异，SLE患者血清抗RPLP0抗体水平高于DLE患者，且与关节损害、肾损害

3、及特征性皮损相关。关键词盘状红斑狼疮：系统性红斑狼疮；皮肤损害：抗RPLP0抗体Thestudyonsermnlevelandclinicalsignificanceofanti·ribosomalproteinPOantibodyinDLEandSLEpatientsDUYah—yu，TANGuo—zhen，YERui—xin，CHEN∞一xia．DepartmentofDermatology，SUNYAT-SENMemorialHospitalofSunYat—senUniversity，Guangz

4、hou510120，China【Abstract】0bjectivesTostudytheserumlevelandtheclinicalsignificanceofanti—ribosomalproteinP0antibodyindiscoidlupuserythematosus(DLE)andsystemiclupuserythematosus(SLE)patients．MethodsSerumanti．RPLP0IgGantibodyof18DLEpatientsand23SLEpatientswe

5、retestedbyEnzyme．LinkedImmunosorbentAssay(ELISA)．Directimmunonu0reseence(DIF)wasusedtoexaminedtheimmunoreaetantsfromskinlesion．SerumantibodyandcomplementC3weredetectedbyconventionalmethods．ResultsAnti—ribosomalPOantibodywashigherinSLEpatients(1．23±0．62．me

6、an±SD)thaninpatientswithDLE(0．53±0．18，P<0．001)andhealthycontrols(0．72±0．16，P<0．001)，butwasnodifferenceinthelatertwogroups(P=0．5)．AmongSLEpatients，anti—ribosomalPOproteinantibodyweremuchhigherinpatientswitharthritis，nephritisandspecificskinlesionthaninthos

7、ewithoutthesedisorders(P<0．05)．Anti—ribosomalP0antibodywasnotassociatedwithSLEDAIandCLASI(P=0．012)．ConclusionsThereisnodifferenceofserumanti—ribosomalP0antibodiesbetweenhealthycontrolsandDLEpatients．SLEpatientshavehigherlevelofserumanti—ribosomalP0antibod

8、y，speciallyinthosewithspecificskinlesion．【Keywords】Lupuserythematosus，Discoid；Lupuserythematosus，systemic；Cutaneousinjury；Anti—ribosoma1P0antibody系统性红斑狼疮(systemiclupuserythematosus，性皮损相关的报道，亦无文献报道其他类型的红SLE)是一种复杂的自身免