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1、妊娠期甲状腺功能筛查甲状腺疾病对于全身器官有广泛的影响TheThyroidIncreasedLDLcholesterol2Elevated triglycerides2TheLiverTheIntestinesConstipation4DecreasedGImotility4Decreasedfertility6Menstrualabnormalities6TheReproductiveSystemDepression1Decreasedconcentration1Generallackofinterest1Impairedfetalintellectualdevelop
2、ment7TheBrainDecreasedfunction5Fluidretentionandedema5TheKidneysDecreasedheartrate3Increasedbloodpressure3Decreasedcardiacoutput3Diastolicdysfunction3TheHeart1.NemeroffCB.Clinicalsignificanceofpsychoneuroendocrinologyinpsychiatry:focusonthethyroidandadrenal.JClinPsychiatry.1989;50(suppl):
3、13-20.2.KlausenIC,NielsenFE,HegedüsL,GerdesLU,CharlesP,FaergemanO.Treatmentofhypothyroidismreduceslow-densitylipoproteinsbutnotlipoprotein(a)Metabolism.1992;41:911-914.3.PolikarR,BurgerAG,ScherrerU,NicodP.Thethyroidandtheheart.Circulation.1993;87:1435-1441.4.Vassilopoulou-SellinR,SellinJH
4、.Thegastrointestinaltractandliverinhypothyroidism.In:BravermanLE,UtigerRD,eds.WernerandIngbar’sTheThyroid.7thed.Philadelphia,Pa:Lippincott-RavenPublishers;1996:816-820.5.MosesAM,ScheinmanSJ.Thekidneysandelectrolytemetabolism.In:BravermanLE,UtigerRD,eds.WernerandIngbar’sTheThyroid.7thed.Ph
5、iladelphia,Pa:Lippincott-RavenPublishers;1996:812-815.6.EmersonCH.Thyroidfunctionanddiseaseinthefemale.In:GoldJJ,JosimovichJB,eds.GynecologicEndocrinology.4thed.NewYork,NY:PlenumPublishingCorp;1987:109-133.7.HaddowJE,PalomakiGE,AllanWC,etal.Maternalthyroiddeficiencyduringpregnancyandsubse
6、quentneuropsychologicaldevelopmentofthechild.NEnglJMed.1999;341:549-555.6/11/2021甲状腺疾病与不良妊娠结局甲亢亚临床甲减/甲减单纯低T4血征TPOAb阳性母体产后甲状腺炎（PPT）流产妊娠期高血压疾病胎盘早剥产后出血胎儿早产低出生体重新生儿呼吸窘迫神经精神发育异常6/11/2021甲状腺疾病与妊娠具有许多相似的临床征象疲劳恶心体重增加皮肤，毛发，指甲的改变失眠便秘头晕情绪波动头疼甲状腺疾病怀孕1.SMandel.BestPractice&ResearchClinicalEndocrinolog
7、y&Metabolism2004;18:213-224.“妊娠期间对于甲减的诊断至关重要，因为甲减会对妊娠造成潜在的十分不利的影响。然而，大部分的甲减孕妇不表现出症状…..即使表现出症状的患者也把它们归因于怀孕所造成的。”16/11/2021甲状腺自身抗体的流行率女性TPOAb阳性率高（平均17％）随年龄增加逐年增加育龄妇女中常见男性TOPAb阳性率8.7%40岁以后不再升高JGHollowell,etal.2002JClinEndoMetab87:489-4996/11/2021及时干预对预后的影响p<0.05p<0.01p
