三七总皂苷对慢性酒精性脂肪肝的保护作用研究-论文.pdf

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1、JournalofChinesePharmaceuticalSciences．c朋i—Panaxnotoginsengsaponinsprotectagainstchronicethanol—inducedhepaticsteatosisRenboDing，JiaolinBao，YiweiCao，ChengweiHe，YitaoWang，JianboWanStateKeyLaboratoryofQualityResearchinChineseMedicine,InstituteofChineseMedicalSciences，Universit

2、yofMacau,Macao999078,ChinaAbstraet：Chronicalcoholconsumptioninduceshepaticsteatosis，theearlystageofalcoholicliverdisease(ALD)．TheaimofpresentstudyistoinvestigatetheprotectiveeffectofPanaxnotoginsengsaponins(PNS)againstchronicethanol—inducedhepaticsteatosisinvivo．Micewerepair

3、-fedamodifiedLieber．DeCarliliquiddietcontainingalcoholorisocaloricmaltosedextrinascongo1dietwithorwithoutPNS(200mg／kg．BW)for8weeks．AnimalssupplementedwitbPNSwereprotectedagainsthepaticlipidaccumulationinducedbychronicethanolexposure．Accordingly．PNScouldsignificantlydecreaset

4、heelevationofplasmatriglyceride，plasmaenzymeactivities，i．e．alanineaminotransferase(ALT)andaspIartateaminotransferase(AST)，andhepaticTNF-if,andIL一6levelswhichwereinducedbychronicalcohoIexposure．Inaddition．PNSmarkedlyreducedthelipolysisofwhiteadiposetissue(WAT)thatstimulatedby

5、alcoholfeedingthroughtheinhibitingproteinexpressionofphosphorylationofhormone-sensitivelipase(p—HSL)，ratherthantotalHSL．Furthermore，alcoholexposurealsoenhancedfattyaciduptakecapacityin1iverbyelevatedhepaticCD36expression，whichcouldaaenumedbvPNStreatment．Theseresultsdemonstra

6、tethatPNSsupplementationprotectsagainstchronicethanol-inducedhepaticsteatosis，whichisassociatedwithamelioratingdvsfunctionallipidmetabolismofWATandthereducedinflammatorycytokines．OurfindingssuggestedthatPNSmightbepotentialtobedevelopedasaneffectiveagentforthetreatmentofchron

7、icalcoholicsteatosis．Keywords：Alcoholicfattyliver，Panaxnotoginsengsaponins，Lipolysis，InflammationCLCnumber：R96Documentcode：AArticleID：1003——1057(2014)6——361——081．IntroductionandforpatientswithsevereformsofALD，drugtherapyisurgentlyneeded．Long—termexcessalcoholconsumptionleads

8、toRootofPanaxnotoginseng(Burk．)F．H．Chen，alsofattyliver(hepaticsteatosis)，ch