欢迎来到天天文库
浏览记录
ID:54707574
大小:1021.32 KB
页数:8页
时间:2020-05-04
《三七总皂苷对慢性酒精性脂肪肝的保护作用研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、JournalofChinesePharmaceuticalSciences.c朋i—Panaxnotoginsengsaponinsprotectagainstchronicethanol—inducedhepaticsteatosisRenboDing,JiaolinBao,YiweiCao,ChengweiHe,YitaoWang,JianboWanStateKeyLaboratoryofQualityResearchinChineseMedicine,InstituteofChineseMedicalSciences,Universit
2、yofMacau,Macao999078,ChinaAbstraet:Chronicalcoholconsumptioninduceshepaticsteatosis,theearlystageofalcoholicliverdisease(ALD).TheaimofpresentstudyistoinvestigatetheprotectiveeffectofPanaxnotoginsengsaponins(PNS)againstchronicethanol—inducedhepaticsteatosisinvivo.Micewerepair
3、-fedamodifiedLieber.DeCarliliquiddietcontainingalcoholorisocaloricmaltosedextrinascongo1dietwithorwithoutPNS(200mg/kg.BW)for8weeks.AnimalssupplementedwitbPNSwereprotectedagainsthepaticlipidaccumulationinducedbychronicethanolexposure.Accordingly.PNScouldsignificantlydecreaset
4、heelevationofplasmatriglyceride,plasmaenzymeactivities,i.e.alanineaminotransferase(ALT)andaspIartateaminotransferase(AST),andhepaticTNF-if,andIL一6levelswhichwereinducedbychronicalcohoIexposure.Inaddition.PNSmarkedlyreducedthelipolysisofwhiteadiposetissue(WAT)thatstimulatedby
5、alcoholfeedingthroughtheinhibitingproteinexpressionofphosphorylationofhormone-sensitivelipase(p—HSL),ratherthantotalHSL.Furthermore,alcoholexposurealsoenhancedfattyaciduptakecapacityin1iverbyelevatedhepaticCD36expression,whichcouldaaenumedbvPNStreatment.Theseresultsdemonstra
6、tethatPNSsupplementationprotectsagainstchronicethanol-inducedhepaticsteatosis,whichisassociatedwithamelioratingdvsfunctionallipidmetabolismofWATandthereducedinflammatorycytokines.OurfindingssuggestedthatPNSmightbepotentialtobedevelopedasaneffectiveagentforthetreatmentofchron
7、icalcoholicsteatosis.Keywords:Alcoholicfattyliver,Panaxnotoginsengsaponins,Lipolysis,InflammationCLCnumber:R96Documentcode:AArticleID:1003——1057(2014)6——361——081.IntroductionandforpatientswithsevereformsofALD,drugtherapyisurgentlyneeded.Long—termexcessalcoholconsumptionleads
8、toRootofPanaxnotoginseng(Burk.)F.H.Chen,alsofattyliver(hepaticsteatosis),ch
此文档下载收益归作者所有