欢迎来到天天文库
浏览记录
ID:54596786
大小:156.06 KB
页数:2页
时间:2020-05-02
《右旋美托咪定在全麻诱导中的镇静效应及对丙泊酚用量的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2012年4月第38卷第7期Jian~suMedJ。Aoril2012,v0l38,No.7●论著●右旋美托咪定在全麻诱导中的镇静效应及对丙泊酚用量的影响施正元【摘要】目的观察右旋美托咪定(dexmedetomidine,DM)在全麻诱导中的镇静效应及对丙泊酚用量的影响。方法选择4O例全麻患者随机均分为两组:D组以DM1/~g/kg稀释成10ml静脉泵注8min;C组以生理盐水为对照分别。给药后20min开始泵注丙泊酚0.4mg·kg1.min-,芬太尼1—2~tg/kg和维库溴铵0.8-1.0mg/kg。记录用DM前(To)、用DM后3min(T1)、6min(T2)、9min
2、(T3)、18min(T4)以及插管前(T5)、插管结束后1min(T6)、插管结束后3min(T7)的脑电双频谱指数(BIS)、MAP和HR。记录诱导期丙泊酚用量。结果与TO比较,D组T3和T4时的BIS值从94.6士2.7分别下降至84.9土9.O(P3、无显著性变化(P>0.05)。与T5相比,c组T6和T7时的MAP均明显升高[(77.3±13.5)mmHgvs.(94.4土20.O)iTlrnHg和(92.4土14.8)ITlInHg](P4、文章编号】O253—3685(2O12)07—0827—02SedationefficacyofdexmedetomidineanditsinfluenceoilrequirementofpropofolduringanesthesiainductionsHlZhengyuan.DepartmentofAnesthesia,DanyangPeople'sHospital,Danyang212300,CHlNA[Abstract]ObjectiveToobservetheofdexmedetomidine(DM)anditsinfluenceonrequirementofpropo5、folduringanesthesiainduction.MethodsFortypatientsundergoinggeneralanesthesiawereequallyrandomizedintotwogroupsofD(DM1ttg/kginfusedat20minbeforeanesthesiainduction)andC(infusionofnorlTlalsalineinsteadofDM).Anesthesiainductionwasperformedwithpropofol0.4mg·k·min-,fentanyl1—2/~g/kgandvecuronium0.6、8-1.0rng/kg.Bispectralindex(BIS),heartrate(HR)andmeanarterialpressure(MAP)wererecordedbefore(TO)andat3(T1),6(T2),9(T3)and18(T4)minute'safterDMinfusion,beforeintubation(T5)andat1(T6)and3(T7)minutesafterintubation.Theminimumdoseandtotalamountofpropofolduringinductionwerecalculated.ResulIsCompar7、edtoTO,BISvaluesofgroupDweredectreasedatT3andT4(94.6±2.7vs.84.9±9.0and71.7±11.6)(P
3、无显著性变化(P>0.05)。与T5相比,c组T6和T7时的MAP均明显升高[(77.3±13.5)mmHgvs.(94.4土20.O)iTlrnHg和(92.4土14.8)ITlInHg](P4、文章编号】O253—3685(2O12)07—0827—02SedationefficacyofdexmedetomidineanditsinfluenceoilrequirementofpropofolduringanesthesiainductionsHlZhengyuan.DepartmentofAnesthesia,DanyangPeople'sHospital,Danyang212300,CHlNA[Abstract]ObjectiveToobservetheofdexmedetomidine(DM)anditsinfluenceonrequirementofpropo5、folduringanesthesiainduction.MethodsFortypatientsundergoinggeneralanesthesiawereequallyrandomizedintotwogroupsofD(DM1ttg/kginfusedat20minbeforeanesthesiainduction)andC(infusionofnorlTlalsalineinsteadofDM).Anesthesiainductionwasperformedwithpropofol0.4mg·k·min-,fentanyl1—2/~g/kgandvecuronium0.6、8-1.0rng/kg.Bispectralindex(BIS),heartrate(HR)andmeanarterialpressure(MAP)wererecordedbefore(TO)andat3(T1),6(T2),9(T3)and18(T4)minute'safterDMinfusion,beforeintubation(T5)andat1(T6)and3(T7)minutesafterintubation.Theminimumdoseandtotalamountofpropofolduringinductionwerecalculated.ResulIsCompar7、edtoTO,BISvaluesofgroupDweredectreasedatT3andT4(94.6±2.7vs.84.9±9.0and71.7±11.6)(P
4、文章编号】O253—3685(2O12)07—0827—02SedationefficacyofdexmedetomidineanditsinfluenceoilrequirementofpropofolduringanesthesiainductionsHlZhengyuan.DepartmentofAnesthesia,DanyangPeople'sHospital,Danyang212300,CHlNA[Abstract]ObjectiveToobservetheofdexmedetomidine(DM)anditsinfluenceonrequirementofpropo
5、folduringanesthesiainduction.MethodsFortypatientsundergoinggeneralanesthesiawereequallyrandomizedintotwogroupsofD(DM1ttg/kginfusedat20minbeforeanesthesiainduction)andC(infusionofnorlTlalsalineinsteadofDM).Anesthesiainductionwasperformedwithpropofol0.4mg·k·min-,fentanyl1—2/~g/kgandvecuronium0.
6、8-1.0rng/kg.Bispectralindex(BIS),heartrate(HR)andmeanarterialpressure(MAP)wererecordedbefore(TO)andat3(T1),6(T2),9(T3)and18(T4)minute'safterDMinfusion,beforeintubation(T5)andat1(T6)and3(T7)minutesafterintubation.Theminimumdoseandtotalamountofpropofolduringinductionwerecalculated.ResulIsCompar
7、edtoTO,BISvaluesofgroupDweredectreasedatT3andT4(94.6±2.7vs.84.9±9.0and71.7±11.6)(P
此文档下载收益归作者所有