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时间:2020-05-02
《丙泊酚与依托咪酯麻醉对感染性休克患者细胞免疫功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华医院感染学杂志2012年第22卷第13期ChinJNosocomiolVo1.22No.132012·2757·论著丙泊酚与依托咪酯麻醉对感染性休克患者细胞免疫功能的影响蔡伟红,罗红彤,郑伟萍,应颖(台州恩泽医疗集团路桥医院麻醉科,浙江台州318050)摘要:目的研究丙泊酚与依托咪酯对感染性休克围手术期患者免疫功能的影响。方法选择2009年3月一2010年1O月在医院临床诊断为感染性休克拟行手术病灶清除的患者78例,按患者接受手术次序进行分组:单号为丙泊酚组,双号为依托咪酯组,各39例;两组分别于麻醉诱导前、术毕及术后1、3、7d分别检测CDs、CD4、CD8的百分率及CD/CD
2、。比值。结果两组患者基线资料具有可比性;与麻醉前相比较,两组患者手术结束时CD。与CD的水平均较麻醉前显著降低(P<0.05),其中,丙泊酚组下降更为显著(P3、至麻醉前水平。结论感染性休克围手术期使用依托咪酯对患者免疫功能影响较小。关键词:感染性休克;麻醉;细胞免疫;丙泊酚;依托咪酯中图分类号:R971。‘.2文献标识码:A文章编号:1005-4529(2012)13—2757-03EffectsofpropofolandetomidateanesthesiaoncellularimmunefunctionofsepticshockpatientsCA1wei—hong。LUOHong—tong,ZHENGWei—ping,YINGYing(LuqiaoHospitalofTaizhouEnzeMedicalGroup,Taizhou,Zh4、iang318050,China)Abstract:OBJECTIVETostudytheinfluenceofpropofoloretomidateoncytoimmunityofsepticshockpatientsduringperiperativeperiod.METHODSAtotalof78patientswithsepticshockweredividedintotWOgroups,39caseswererespectivelygivenpropofoloretomidate.ThepercentageofCD3+,C亡+,CD8+andCD4+/CD8+beforei5、nductionofanesthesia,and1,3and7daysalbertandafteroperationwereevaluated.RESULTS.Thebaselinedatawerecomparable;ascomparedwiththatbeforetheanesthesia,bothofthetWOgroupsCD3andCD4attheendofsurgerysignificantlydecreased(P<0.05),whilethepropofolgroupdecreasedthemostsignificantly(P<0.05);CD3andCD4leve6、lsofthetwogroupsbegantorise1dayaftertheoperation,andreturnedbacktothelevelbeforetheanesthesia7daysaftertheoperation;theCD3。。levelofthepropofolgroupwassignificantlylowerthanthatoftheetomidategroup1dayalbertandaftertheoperation(P7、theetomidategroup3daysalbertandaftertheoperation(P
3、至麻醉前水平。结论感染性休克围手术期使用依托咪酯对患者免疫功能影响较小。关键词:感染性休克;麻醉;细胞免疫;丙泊酚;依托咪酯中图分类号:R971。‘.2文献标识码:A文章编号:1005-4529(2012)13—2757-03EffectsofpropofolandetomidateanesthesiaoncellularimmunefunctionofsepticshockpatientsCA1wei—hong。LUOHong—tong,ZHENGWei—ping,YINGYing(LuqiaoHospitalofTaizhouEnzeMedicalGroup,Taizhou,Zh
4、iang318050,China)Abstract:OBJECTIVETostudytheinfluenceofpropofoloretomidateoncytoimmunityofsepticshockpatientsduringperiperativeperiod.METHODSAtotalof78patientswithsepticshockweredividedintotWOgroups,39caseswererespectivelygivenpropofoloretomidate.ThepercentageofCD3+,C亡+,CD8+andCD4+/CD8+beforei
5、nductionofanesthesia,and1,3and7daysalbertandafteroperationwereevaluated.RESULTS.Thebaselinedatawerecomparable;ascomparedwiththatbeforetheanesthesia,bothofthetWOgroupsCD3andCD4attheendofsurgerysignificantlydecreased(P<0.05),whilethepropofolgroupdecreasedthemostsignificantly(P<0.05);CD3andCD4leve
6、lsofthetwogroupsbegantorise1dayaftertheoperation,andreturnedbacktothelevelbeforetheanesthesia7daysaftertheoperation;theCD3。。levelofthepropofolgroupwassignificantlylowerthanthatoftheetomidategroup1dayalbertandaftertheoperation(P7、theetomidategroup3daysalbertandaftertheoperation(P
7、theetomidategroup3daysalbertandaftertheoperation(P
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