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时间:2020-05-02
《儿童支气管哮喘与维生素D水平的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国医院统计2014年4月第2l卷第2期儿童支气管哮喘与维生素D水平的相关性研究刘晓娟钟文明吴智娟【摘要】目的探讨维生素D(VitD)在儿童支气管哮喘患者中的水平分布,研究VitD水平与儿童哮喘的相关性,为早期预防和治疗儿童哮喘提供依据。方法采用病例对照的研究方法,将确诊的60例儿童哮喘患者作为病例组,同时收集60例非支气管哮喘患儿作为对照组;采用诊断试验ROC、多元线性回归及多因素Logistic回归分析等方法研究VitD与儿童哮喘发病的相关性。结果哮喘组的VitD水平为53.32-4-15.75nmol/L,明显低于对照组的85.70-4-
2、23.99nmol/L(P3、ndvitaminDlevelLiuXiaojuan,ZhongWenming,WuZh。n.DepartmentofTraditionalChineseMedicine,Maternity&ChildHealthCareofBaoanDistrict,Shenzhen518133,China【Abstract】ObjectiveToexplorethedistributionofVitaminD(VitD)levelinthepatientsofbronchialasthma,andstudycorrelationbetweenVitDand4、childrenbronchialasthma,toprovidebasisforearlyinterveningandtreatingbronchialasth—ma.MethodsWithcase—controlstudymethod,60casesofdefinitechildrenbronchialasthmawerecollectedascasegroupand60casesofnon-bronchialasthmaascontrolgroup.DiagnosticROC,multipleLinealRegressionandmult5、iplefactorsLogisticRe-gressionmethodswereusedtoanalyzethecorrelationbetweenVitDandchildrenbronchialasthma.ResultsThelevelofVitDintheasthmagroupwas53.32+15.75nmol/L,muchlowerthanthecontrolgroup(85.70+23.99nmolfL)(P<0.01).UseofVitDscreeningasthma.ROCresultshowedthatthesensitiv6、itywas71.7%andthespecificitywas90.O%.MultipleLinealRegressionresultshowedthatasthmaticattacktimesinthepreviousyearandIgEwerenegativecorelationwithchildrenasthma,butCD4/CD8waspositivecorrelationwithasthma.MultiplefactorsLogisticRegressionindicatedthatVitDandCD8weretheprotecti7、vefactorsofchildrenasthma,butIgEwastheriskfactorofchildrenasthma.ConclusionChildrenbronchialasthmaisintimatecorrelationwithVitD,SOitisveryimportanttopreventandinterventchildrenbronchialasthmawithVitDdeficiency.【Keywords】ChildrenBronchialasthmaAsthmaVitaminDCorrelation儿童支气管哮喘8、(简称哮喘)的发病率在世界范所确诊的儿童支气管哮喘患者作为研究病例,诊断依围内不断增加,导致这种趋势的原因可能是由于人们据为《儿童支气管哮喘诊断与防治
3、ndvitaminDlevelLiuXiaojuan,ZhongWenming,WuZh。n.DepartmentofTraditionalChineseMedicine,Maternity&ChildHealthCareofBaoanDistrict,Shenzhen518133,China【Abstract】ObjectiveToexplorethedistributionofVitaminD(VitD)levelinthepatientsofbronchialasthma,andstudycorrelationbetweenVitDand
4、childrenbronchialasthma,toprovidebasisforearlyinterveningandtreatingbronchialasth—ma.MethodsWithcase—controlstudymethod,60casesofdefinitechildrenbronchialasthmawerecollectedascasegroupand60casesofnon-bronchialasthmaascontrolgroup.DiagnosticROC,multipleLinealRegressionandmult
5、iplefactorsLogisticRe-gressionmethodswereusedtoanalyzethecorrelationbetweenVitDandchildrenbronchialasthma.ResultsThelevelofVitDintheasthmagroupwas53.32+15.75nmol/L,muchlowerthanthecontrolgroup(85.70+23.99nmolfL)(P<0.01).UseofVitDscreeningasthma.ROCresultshowedthatthesensitiv
6、itywas71.7%andthespecificitywas90.O%.MultipleLinealRegressionresultshowedthatasthmaticattacktimesinthepreviousyearandIgEwerenegativecorelationwithchildrenasthma,butCD4/CD8waspositivecorrelationwithasthma.MultiplefactorsLogisticRegressionindicatedthatVitDandCD8weretheprotecti
7、vefactorsofchildrenasthma,butIgEwastheriskfactorofchildrenasthma.ConclusionChildrenbronchialasthmaisintimatecorrelationwithVitD,SOitisveryimportanttopreventandinterventchildrenbronchialasthmawithVitDdeficiency.【Keywords】ChildrenBronchialasthmaAsthmaVitaminDCorrelation儿童支气管哮喘
8、(简称哮喘)的发病率在世界范所确诊的儿童支气管哮喘患者作为研究病例,诊断依围内不断增加,导致这种趋势的原因可能是由于人们据为《儿童支气管哮喘诊断与防治
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