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时间:2020-05-02
《体外循环期间不同血气管理方法对脑组织血流和氧代谢的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、肺血管病杂志2014年3月第33卷第2期Journal0fCardiovascular&Pulm0naryDisease8,March2014,Vo1.33,N0.2237DO1:10.3969/j.issn.1007-5062.2014.02.023·临床论著·体外循环期间不同血气管理方法对脑组织血流和氧代谢的影响贾在申谢海秀孙志全刘媛李蛟侯晓彤[摘要]目的:比较两种血气管理方法,对中浅低温双瓣膜置换体外循环期间,大脑血流速度和氧代谢的影响。方法:选取连续24例中浅低温体外循环下行双瓣膜置换患者,使用CDI
2、500进行连续血气监测。分别于以下5个时间点:麻醉诱导后(T),体外循环转机10min时(T2),当鼻咽温降至25~C时,使用仅稳态管理并校正血气15min后(T3),后改用pH稳态管理并校正血气15min后(T4),停机后10min(T),使用经颅多普勒超声仪和近红外线光谱仪,测定大脑中动脉血流速度和脑氧饱和度,评估不同血气管理方法的脑保护效果。结果:与Tl相比较,T2、T]脑血流速度和脑氧饱和度均有所减少,但差异无统计学意义(P>0.05)。与T3相比较,T4时间点大脑血流速度和脑氧饱和度稍有升高,但差异
3、并无统计学意义(P>0.05)。结论:中浅低温体外循环期采用pH稳态血气管理并未明显增加大脑血流速度和氧供。[关键词]中低温;体外循环;血气管理;脑血流;脑氧饱和度[中图分类号]1154[文献标志码]A[文章编号]1007-5062(2014)02-237-04EfectsofpH-statversusalpha·statstrategiesoncerebralbloodflowandcerebraloxygensaturationdu~ngmoderatehypothermiccardiopulmonary
4、bypassJIAZaishen。XIEHaixiu.SUNZhiquan,HUYuan,LIJiaoHOUXiaotongDepartmentofExtracorporealCirculatory,CenterforCardiacIntensiveCare,CapitalMedicalUniversityafiliatedBeingAnzhenHospital,BeijingInstituteofHeart,LungandBloodVesselDiseases,Being100029,China[Abstr
5、act]Objective:Tocomparetheeffectofalpha—statversuspH—statstrategiesforacid—baseman-agementoncerebralbloodflowandregionalcerebraloxygensaturationinpatientsundergoingmoderatehypot-hermiccardiopulmonarybypass.Methods:In24adultpatientsundergoingelectivedoubleva
6、lvereplacementoperationwerestudied.Thecerebralbloodflow(CBF)andregionalcerebraloxygensaturation(rSO2)weremonitoredusingTCDandNIRSatfivetimepoints:inductionofanesthesia(T1),after10minofthebeginningofcardiopulmonarybypass(T2)andduringthemoderatehypothermiepha
7、seofCPBmanagedbythealpha-stataf-tercalibratebloodgas15min(T3),andpH—statfollowed,aftercalibratebloodgas15min(T4),10minafterCPB(T5)Results:ThevaluesofCBFandrSO2ofT2andT3werenotsignificantlydecreasedcomparewiththatofT1(P>0.05).ThevaluesofT4slightlyincreasedco
8、mparewiththatofT3,butitisnotsignificant(P>0.05).Conclusion:Duringmoderatehypothermiccardiopulmonarybypass,thecerebralbloodflowandtherSO2werenosignificantlyhigherduringpH—statthanthatofalpha—stat.[Keywo
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