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《右美托咪定对小儿心脏手术麻醉中血流动力学及应激反应的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·96·ShanghaiMedJ,2012,Vo1.35,No.2●/J、L麻醉●右美托咪定对&JL心脏手术麻醉中血流动力学及应激反应的影响凌云志孙瑗梁启胜李晓红禹莉徐浣白【摘要】目的探讨右美托咪定在4qL心脏手术麻醉中对血流动力学和应激反应的影响。方法3O例在体外循环(CPB)下实施心脏手术的患儿被随机分为试验组和对照组,每组l5例。试验组经静脉微量注射泵注射右美托咪定,而对照组注射等量0.9氯化钠溶液。监测两组患儿在术中颈内静脉置管后(T,)、劈胸骨后(T2)、CPB前(T)、CPB结束时(T)、气管导管拔管时(Ts)的平均动脉压(MAP)和心率(HR)
2、。记录T、Tz、T。和T时间点的脑电双频指数(BIS)值,记录T时间点的Ramsay镇静评分。同时测定术中5个时间点的血糖、皮质醇及醛固酮水平。结果试验组在术中各时间点的MAP均显著低于对照组同时间点(P值分别<0.05、0.01),T、T、T时间点的HR显著低于对照组同时间点(P值分别0.05)。试验组在Ts时间点的Ramsay镇静评分显著高于对照组(P<0.05)。试验组在T、T:、T。和T时间点的血糖水平均显著低于对照组同时间点(P值均<0.01),T。、T。、T和
3、Ts时间点的皮质醇水平均显著低于对照组同时间点(P值均4、;应激反应EffectsofdexmedetomidineonhemodynamicsandstressreactioninpediatricpatientsundergoingcardiacsurgeryLINGYunzhi,SUNYcan,LIANGQisheng,LIXiaohong,YULi,XUHuanbai.DepartmentofAnesthesiology,TheFirstAfiliatedHospitalofBengbuMedicalCollege,Bengbu233000,Anhui,Chine[Abstract]ObjectiveToi5、nvestigatetheefectofdexmedetomidineonhemodynamicsandstressreactioninpediatricpatientsundergoingcardiacsurgery.MethodsThirtychildrenundergoingcardiacsurgerywithcardiopulmonarybypass(CPB)wererandomlydividedintoexperimentalgroupandcontrolgroup(n=15).Equivalentdexmedetomidineand0.9%sod6、iumchloridesolutionwerepumpedfortheexperimentaIgroupandcontrolgroup,respectively.Themeanarterypressure(MAP),heartrate(HR),bloodglucose,cortisolandaldosteroneweredeterminedafterjugularveincannulation(T1),aftersplittingthesternum(T2),beforeCPB(T3),attheendofCPB(T4),andattheextubation7、(T5).Bispectralindex(BIS)atT1,T2,T3andT4andRamsayscoreatT5wererecorded.ResultsTheMAPinexperimentalgroupwassignificantlylowerthanthatincontrolgroupatthe5timepoints(P0.08、5),whileRamsaysedationscor
4、;应激反应EffectsofdexmedetomidineonhemodynamicsandstressreactioninpediatricpatientsundergoingcardiacsurgeryLINGYunzhi,SUNYcan,LIANGQisheng,LIXiaohong,YULi,XUHuanbai.DepartmentofAnesthesiology,TheFirstAfiliatedHospitalofBengbuMedicalCollege,Bengbu233000,Anhui,Chine[Abstract]ObjectiveToi
5、nvestigatetheefectofdexmedetomidineonhemodynamicsandstressreactioninpediatricpatientsundergoingcardiacsurgery.MethodsThirtychildrenundergoingcardiacsurgerywithcardiopulmonarybypass(CPB)wererandomlydividedintoexperimentalgroupandcontrolgroup(n=15).Equivalentdexmedetomidineand0.9%sod
6、iumchloridesolutionwerepumpedfortheexperimentaIgroupandcontrolgroup,respectively.Themeanarterypressure(MAP),heartrate(HR),bloodglucose,cortisolandaldosteroneweredeterminedafterjugularveincannulation(T1),aftersplittingthesternum(T2),beforeCPB(T3),attheendofCPB(T4),andattheextubation
7、(T5).Bispectralindex(BIS)atT1,T2,T3andT4andRamsayscoreatT5wererecorded.ResultsTheMAPinexperimentalgroupwassignificantlylowerthanthatincontrolgroupatthe5timepoints(P0.0
8、5),whileRamsaysedationscor
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