住院极低出生体重儿细菌感染的影响因素分析

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1、·340·中国新生儿科杂志2008年第23卷第6期·论著·住院极低出生体重儿细菌感染的影响因素分析侯莹李士胃支0博【摘要】目的分析极低出生体重儿(VLBWI)细菌感染的临床表现，探讨其相关临床影响因素。方法2006牟1月至20o7牟1月出生24h转入新生儿科的VLBWI121例作为研究对象，记录惠儿病情变化时的临床表现及实验室检查结果，并通过统计学方法得出其相关临床影响因素。结果住院期间感染43例共68例次，感染发生率为56．2％(68／121)。感染1次者21例，≥2次者22例。确定诊断7例次，临床诊

2、断6l例次。其中早发感染(感染发生于生后48～72h)l4例次(14／121、11．6％)；迟发感染54例次(感染发生于72h后)(54／121、44．6％)。出生体质量

3、I发生感染，应根据临床特点早期发现、积极治疗。【关键词】婴儿，极低出生体重；细菌感染；临床试验AnanalysisofclinicalinfluentialfactorsofbacterialinfectionamongverylowbirthweightinfantsinhospitalHOUYing，LIJuan，LIUBo．Departmentofnewborn，AfiliatedHospitaltoChinaMedicalUniversity，Shenyangl10004．ChinaCorres

4、pondingauthor：LIJuan，Emai：l~uanS@yahoo．con．cn【Abstract】ObjectiveToexplorevariousmanifestationsofbacterialinfectionamongverylowbirthweightinfantsfVLBWI)inhospitalandtheirassociatedfactors．Methods121VLBWIintheHospitalwereunderstudy，43sufferedfrombacteriali

5、nfectionatdifferenttimeofbirth．theirclinica1manifestationsandlaboratoryexaminationswereanalyzed．Thecorrelationswereestimatedthroughstatisticalcalculation．ResultsAtota】of68bacterialinfectionoccurredamong43infantsinhospitalwithaprevalenceof56．2％(68／121)．Du

6、ringthehospitalization，therewere22infantswithonetimeinfection．7infantswithmorethan2timesofinfection．Seveninfectionswithdefinitediagnoses．sixty—onewerediagnosedclinically．Fourteeninfectionswereearly—onset(14／121，l1．6％)；Fifty—fourwerelate-onsetinfection(54

7、／121，44．6％)．Theearlybacterialinfectionmanifestationsincludefrequentapnea，feedingintolerance，illappearingormottlingskinwithhypothermia，abdominaldistention，delayedgrowth，respiratorydistressetc．Withlogisticregressionmodeltoanalyzeclinicaldata，prolongedruptu

8、reofmembrane，lowbirthweight<1kg，<32gestationalage，mechanicalventilation，tubefeedingwouldcauseinfectioninprematureinfant．ConclusionMuhicasualoriginscreateinfectionfactorsinhospitalizedVLBWI．Abnormalclinicalsignsshouldbenoti