45例间变性大细胞淋巴瘤临床病理特点及疗效分析

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1、肿瘤防治研究2011年第38卷第1期·59·DOI：1【)．3971／J．issn．1()()()8578．2011．01．01745例间变性大细胞淋巴瘤临床病理特点及疗效分析贺彬彬，杨彬AnalysisofClinic0path0lOgicalCharactersandOutcomesof45PatientswithAnaplasticLargeCellLymphomaHEBin—bin，YANGBinDepartmentoMedi~，alOncology，HubeiCancerHospital，Wldl~ln4

2、3{}079，Chi71aAbstract：ObjectiveToinvestigatethefactorsaffectontheclinicopathologicalcharacters，theout—cometreatmentandtheprognosticofanaplasticlargecelllymphoma(AICL)．MethodsTheclinicaldataof45patientswithAIIwhoreceivedtreatmentinourhospitalfromJan2()()()toDec

3、：2(}08wereanalyzedretrospectively．ThesurvivalwasestimatedbyKaplan—MeierandtheprognosticfactorswereanalyzedwithCoxmode1．Results84．4(38patients)and15．6(7patients)wereprimarycuta—neousandsystemicALCLrespectively．Twentypatients(44．4)manifestedwithsystemicsymp—toms

4、and8patients(21．6)withelevatedleveloflactatedehydrogenase．AccordingtotheInterna—tionalPrognosticIndex(IPI)ofNon—Hodgkinlymphoma，31patients(68．9％0)werethelowandlowintermediaterisk．Andanaplsticlymphomakinase(ALK)waspositivein28patients(62．2)．26patients(57．8)were

5、T—ce1lorigin，6ones(13．37o)weret3-celloriginmarkers11ones(22．2)werenulltypeandboththeT-cellandB-cel1markerswerepositiveintheothertwopatients(4．4)．Theresponserates，5-yearoverallsurvivalratesofprimarycutaneousandsystemicALCIwere⋯()and92．1，83．3and63．9(=0．7()7，P=0．

6、4()1)respectively．The5-yearoverallsurvivalratesofpatientswithpositiveandnegativeALKwere87．5and46．9％o(y=10．992，P=0．01)．Withtheunivariateanalysis，theexpressionofALK(P=0．()1)，thescoreofIPI(P=0．000)andtheclinicalstaging(P=I)．OO5)weretheprognosticfactorsaffecttheov

7、erallsurviva1．Withmultivariateanalysis，bothALK(0．012)andIPI(P=()．()()())weretheindependentprognosticfactors．ConclusionApproximately，80ofALCIareprimarysystemicand60ofpatientsexpresstheALK．Boththeresponseandthesurvivalaresatisfied．TheAIKandIPIscorearetheindepend

8、entprognosticfac—torsaffecttheoverallsurviva1．Keywords：Lymphoma；Anaplasticlargecell；Efficiency；Prognosis摘要：目的分析问变性大细胞淋巴瘤(ALCI)的临床病理特点、远期效果和影响预后的因素。方法回顾性分析2{}00年1月一2()()8年12月我院收治的45