肌酸激酶同工酶、肌钙蛋白及超敏C-反应蛋白联合检测对手足口病患儿心肌损害临床意义.doc

《肌酸激酶同工酶、肌钙蛋白及超敏C-反应蛋白联合检测对手足口病患儿心肌损害临床意义.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、肌酸激酶同工酶、肌钙蛋白及超敏c-反应蛋白联合检测对手足口病患儿心肌损害临床意义［摘要］目的探索肌酸激酶同工酶、肌钙蛋白及超敏c-反应蛋白联合检测对手足口病患儿心肌损害的临床意义。方法选取本院2011年6月〜2011年12月期间诊治的105例手足口病患儿，全部纳入观察组；另随机选取同期门诊健康体检儿童60例，纳入对照组；观察组和对照组均开展肌酸激酶(CK)、肌酸激酶同工酶(CK-MB).肌钙蛋白(cTnl)及超敏C-反应蛋白(hs-CRP)等指标的水平检测。结果观察组患儿心肌损害率为47.62%,对照组为6.67

2、%,两组比较观察组显著高于对照组(P<0.01)；观察组患儿的CK、CK-MB、cTnl及hs-CRP检测水平均明显髙于健康对照组儿童(P均〈0.01)o结论在对手足口病患儿开展早期诊治时，应紧密结合心肌酶、肌钙蛋白、C-反应蛋白等临床检测指标结果，早期诊断手足口病小儿是否发生心肌损坏，以及早采取治疗措施。［关键词］手足口病；心肌损害；肌酸激酶；CK-MB、cTnl及hs-CRP水平检测［中图分类号］R725.1［文献标识码］B［文章编号］1674-4721(2012)07(b)-0107-02Clinicals

3、ignificanceofjointdetectionofcreatinekinaseisoenzymes,troponinandhigh-sensitivityC-reactiveproteinonmyocardialdamageinchildrenwithhandfootandmouthdiseaseWEIHuaThePeople"sHospitalofPeiCountyinJiangsuProvince,PeiCounty221600,China[Abstract]ObjectiveToobservethe

4、clinicalsignificanceofjointdetectionofcreatinekinaseisoenzymes,troponinandhigh-sensitivityC~reactiveproteinonmyocardialdamageinchildrenwithhandfootandmouthdisease・MethodsOnehundredandfivechildrenwithhandfootandmouthdiseasetreatedinourhospitalfromJune2011toDec

5、ember2011wereselectedandallincorporatedintotheobservationgroup.And60childrenwithoutpatienthealthphysicalexaminationofthecorrespondingperiodwerechosenrandomlyandincorporatedintothecontrolgroup.Theobservationgroupandthecontrolgroupalldetectedtheindexlevelofcrea

6、tinekinaseisoenzymes,troponinandC-reactiveprotein,etc・ResultsThemyocardialdamagerateoftheobservationgroupwas47.62%,asforthecontrolgroup,themyocardialdamageratewas6.67%.Bycomparison,theobservationgroupwassignificantlyhigherthanthoseinthecontrolgroup(P<0.01).Th

7、edetectionlevelofcreatinekinaseisoenzymes,troponinandC~reactiveproteininchildrenoftheobservationgroupwerehigherobviouslythanthecontrolgroupofhealthychildren(P<0.01)・ConclusionInearlydiagnosisandtreatmentofchildrenwithhandfootandmouthdisease,thedetectionofclin

8、icalindexesofcreatinekinaseisoenzymes,troponinandC-reactiveproteinshouldbecombined,anddiagnosewhetherthepatientswithhandfootandmouthdiseaseoccurmyocardialdamagetotakeearlytreatmentmeasure