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1、慢性酒精中毒性周围神经病的临床电生理学研究【摘要】目的探讨神经电生理检测对慢性酒精中毒性周围神经病的诊断价值。方法对35例慢性酒精中毒患者进行电生理检查,观察肌电图(EMG)、运动神经传导速度(MCV)和感觉传导速度(SCV)的变化情况。结果35例患者EMG检查综合判断提示神经源性损害,上下肢EMG异常差异无显著性(P>0.05),年龄与EMG异常无明显相关性。SCV较対照组有不同程度的减慢(PV0.01),而MCV改变不明显(P>0.05);SCV异常率为81.43%,□异常程度与饮酒年限呈正相关系(「=0.54,PV0.01);15例双上肢无临床症状的患者中10
2、例(66.67%)尺神经SCV有改变。结论神经电生理检测为慢性酒精屮毒性周围神经病的临床诊断特别是早期诊断提供了客观依据。【关键词】慢性酒精中毒周围神经病经电生理AClinicalandElectrophysiologicalStudyofPeripheralNeuropathyAttributedtoChronicAlcoholismLIUSu-yun,LINai-li,YUANJing,MINLian-qiu1.DepartmentofEMG;2.Neuromedic^dDepartment,theFirstAffiliatedHospital,Liaoning
3、MedicalUniversity,Jinzhou121000China[Abstract]ObjectiveThispaperhasexploredthediagnosisvalueofelectrophysiologicalexaminationintoperipheralneuropathyresultingfromchronicalcoholism.MethodsThroughelectrophysiologicalexaminationinto35patientswhosufferedfromchronicalcoholism,thechangesofth
4、eirelectroniyograni(EMG),niotoriusconductionvelocity(MCV)andsenseconductionvelocity(SCV)wereobserved.ResultsTheEMGofthe35patientsindicatedthattheirneuronewevehamied.TherewevenoobviousdifferencesinEMGofbothupperandlowerlimbs(P>0.05).Therewasnoobviousrelationbetweenageandthedifferencesin
5、EMGIncomparisonwiththecontrolgroup,andSCVwassloweddowninsomedegree(P<0.01),yetthechangeofMCVwasnotevident(P>0.05);therateofabnormitywas81.43%,andthedegreeofabnormitywasproportionaltothelengthofdrinkinghistory(r=0.54,P<0.01);amongthe15patients,bothoftheirupperlimbshadenoclinicalsymptoms
6、andtherewere10patientswhoseSCVoftheulnarnerveshadsomechanges.ConclusionsNeuro-electrophysiologicalexaminationprovidesobjectivebasisforthediagnosisofperipheralneuropathyduetochronicalcoholism,especiallyfortheearlyone.[Keywords]chronicalcoholism;peripheralneuropathy;neuro-electrophysiolo
7、gy慢性酒精中毒性多发性神经病(chronicalcoholismperipheralneuropathy,CAPN)是由于长期大最饮酒引起的中枢及周围神经损害,以周圉神经病发病率最高,且给病人带来极大痛苦,我国发人数呈逐年增加趋势。我们于2001年8月至2005年6月对35例慢性酒精中毒患者进行临床与神经电生理检查,以评价其对慢性酒精中毒性周围神经病早期诊断价值。1资料与方法1.1一般情况35例患者均为男性,年龄34〜75岁,平均年龄(54.5±8.5)岁。所有患者均有长期饮用高度烈性白酒史,饮酒度数38〜60度,10例患者间断饮用低度酒(啤酒)。饮酒年限为6