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《妊娠期糖尿病患者肾损害与血清Cys C水平的相关性研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、国际检验医学杂志2014年5月第35卷第1O期IntJLabMed,May2014,V0I_35,No.10·临床检验研究论著·妊娠期糖尿病患者肾损害与血清CysC水平的相关性研究邱先桃,丘媛媛,代玉梅△,顾晓琼,张素娟,蔡敏敏(广州市妇女儿童医疗中心检验科,广东广州510630)摘要:目的探讨妊娠期糖尿病(GDM)患者肾损害与血清胱抑素c(Cysc)的相关性。方法回顾性分析2011年1月至2012年12月于该中心顺产单胎的产妇,选择经口服葡萄糖耐量试验(OGTT)检测确诊为GDM的400例产妇,将孕3o~4o周检测的24h
2、尿蛋白量大于0.15g的200例产妇作为GDM组,而将24h尿蛋白量不高于0.15g的200例产妇作为GDM对照组。将排除GDM的200例健康产妇作为正常组。于孕3O~40周检测血清尿酸、肌酐、尿素、CysC,并检测24h尿蛋白量。结果GDM组患者血清尿酸、CysC水平高于GDM对照组(P0.05);24h尿蛋白量与血清尿酸、Cysc呈正相关(r分别为0.715、0.863,P%0.05),与尿素、肌酐无明显相关(P>0.05)。结论血清CysC可作为GDM患者肾损害
3、的早期诊断及监测指标。关键词:糖尿病,妊娠;肾损害;胱抑素C;尿蛋白DOI:10.3969/i.issn.1673—4130.2014.10.024文献标识码:A文章编号:1673—4l30(2014)10—1289—02AresearchofcorrelationbetweenrenaldamageofpatientswithgestationaldiabetesmellitusandlevelofserumcystatinCQiuXiantao,QiuYuanyuan,DaiYumei,GuXiaoqiong,Zhang
4、Sujuan,CaiMinmin(Depart.tento,’ClinicalLaboratory,GuangzhouWomenandChildrenMedicalCenter,Guangzhou,Ouangdong510630,China)Abstract:ObjectiveToexplorethecorrelationbetweenrenaldamageofpatientswithgestationaldiabetesmellitus(GDM)andlevelofserumcystatinC(CysC).MethodsE
5、utociapuerperaswithsinglebirthinthiscenterfromJanuary2011toDecember2012wereretrospectivelyanalyzed.400puerperas,whowereconfirmedasGDMbyoralglucosetolerancetest(OGTT)detection,werecollected.Amongthem,200puerperaswith24hurinaryproteincontentmorethan0.15gduringtheir30
6、to40weeksofpregnancywereservedasGDMgroup,whileanother200puerperaswiththosenotmorethan0.15gasGDMcontrolgroup.200healthypuer—peraswithoutGDMwereservedasthenormalgroup.Serumuricacid,creatinine,urea,CysCand24hurinaryproteincontentofthemduringtheir30to40weeksofpregnancy
7、weredetected.ResultsSerumuricacidandCysCofpatientsinGDMgroupwereobviouslyhigherthanthoseintheGDMcontrolgroup(P~0.05),whilethedifferencesofserumurea,creatininebetweenthetwogroupsshowednostatisticalsignificance(P>O.05).24hurinaryproteincontentwaspositivelycorrelatedw
8、iththeserumuricacidandCysC(r一0.715,0.863,P<0.05),andhadnocorrelationwithureaandcreatinine(P>0.05).ConclusionSerumCysCmaybeusedasindicatorsforearl
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