参附注射液对心衰患者血清NT-proBNP水平的影响及疗效评价-论文.pdf

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1、第26卷第1期菏泽医学专科学校学报VOL．26N0．12014伍J0URNAL0FHEZEMEDICALCOLLEGE2014DOI：10．3969／j．issn．1008—4118．2014．01．20参附注射液对心衰患者血清NT-proBNP水平的影响及疗效评价桑贤德，张凤仙，姚书迪(牡丹区中心医院，山东菏泽274000)摘要：目的探讨参附注射液对心肾阳虚型充血性心力衰竭(CHF)患者血清N末端前B型利钠肽(NT—proBNP)水平的影响。方法选择68例心肾阳虚型CHF患者，随机分为常规32例，参附注射液组36例，分别给予常规治疗和在常规治疗基础上参附注射液治

2、疗；两组患者治疗前后均测定或计算血清NT—proBNP、左室射血分数(LVEF)、左室短轴缩短率(FS)、每搏输出量(SV)、心输出量(CO)、心脏指数(CI)及临床征候积分；采用免疫荧光测定法检测血清NT’proBNP浓度。结果血清NT—proBNP水平与心衰严重程度呈正相关；治疗后参附注射液治疗组与常规组血清NT—proBNP含量均明显降低，与治疗前相比，有显著性差异(P<0．01)，参附注射液组比常规治疗组有一定优势(P<0．05)；参附注射液组与常规治疗组治疗后LVEF、FS、SV、CO、CI等心功能指标均有明显改善，与治疗前相比具有非常显著性差异(P<0

3、．01)；参附注射液治疗组LVEF、FS、SV、CO较常规治疗组改善更为明显(尸<0．05)。两组治疗后心功能分级及中医证候积分均有明显改善(P<0．01)，但参附注射液组比常规治疗组更有优势(P<0．05)。结论参附注射液能有效降低心肾阳虚型CHF患者NT—proBNP水平，改善心功能，中西医结合治疗优于常规西医治疗。关键词：心力衰竭／治疗；中西医结合疗法；N末端前B型利钠肽中图分类号：R541．61文献标识码：A文章编号：1008—4118(2014)0卜0035—04TheEffectandTherapeuticEvaluationofNT‘proBNPLe

4、velofPatientsTreatedwithShenfuInjectionSangXiande,ZhangFengxian,YaoShudirCentralHospitalofPeonyDistrict,Heze274000,ShandongJAbstract：ObserveTheimpactofginsengandaconiteinjectiononthelevelsofserumNterminalandformerb—typenatriureticpeptide(NT—proBNP)ofpatientswithYangdeficiencyofheartan

5、dkidneyandcongestiveheartfailure(CHP)．MethodsChoose68casesofCHFpatientswithYangdeficiencyofheartandkidney，randomlydividedinto32casesofconventionaltreatmentgroup，and36casesofinjectiontreatmentgroup，givenconventionaltreatmentandconven—tionalwithinjectiontreatmentrespectively．Twogroupsof

6、patientsweremeasuredorcalculatedserumNT—proBNP，leftventricularejectionfraction(LVEF)，leftventricularshortaxisshorteningrate(FS)output，strokevolume(sv)，cardiacoutput(co)，cardiacindex(CI)andclinicalsymptomcreditsbe~reandaftertreatment．3，Usingimmunofluorescenceas—saytodetectserumNT—proBN

7、Pconcentration．ResultsNT—proBNPserumlevelwasposiivelycorrelatedwithsever—ityofheartfailure．TheserumcontentofNT—proBNPofinjectiontreatmentgroupandconventionaltherapygroupaftertreatmentwereobviouslylower．Comparedwithbefore，thedifference(尸

8、tgrou