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《替吉奥联合顺铂治疗晚期胃癌的近期疗效观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中国肿瘤临床与康复2012年1O月第19卷第5期ChinJClinOncolRehabil,October2012,Vol19,No.5·425··临床应用·替吉奥联合顺铂治疗晚期胃癌的近期疗效观察时淑珍曲范杰于韦韦张捷(大连市第三人民医院肿瘤内科,大连116033)【摘要】目的探讨替吉奥联合顺铂治疗晚期胃癌的有效性和安全性。方法采用非盲法随机对照试验。治疗组27例,替吉奥胶囊根据体表面积给药,<1.25m,40mg,bid;1.25—1.50m,50mg,bid;>1.50m,60mg,bid,早晚餐后口服,d1~d14。顺铂:75mg/m,dl—d3,21d为一疗程。对照
2、组26例,5一Fu600mg·m~·d以微量泵进行持续静脉滴注,d1~d5;顺铂20mg·m一·d~,静脉滴注,d1一d5。28d为一疗程。每完成2个周期复查评价疗效和生活质量状况,观察并记录不良反应。结果治疗组有效率为59.3%,对照组为19.2%,两组间比较差异有统计学意义(P=0.005)。临床获益率比较,治疗组为88.9%,对照组为53.8%,两组间比较差异有统计学意义(P=0.006)。治疗前后治疗组与对照组患者KPS评分改善情况差异有统计学意义(P=0.035),治疗后对照组KPS评分降低较治疗组有显著性差异(P=0.006)。两组患者主要不良反应为消化道毒性、血
3、液学毒性和肝脏毒性,两组间比较差异无统计学意义(P>0.05)。结论替吉奥联合顺铂治疗晚期胃癌安全、有效。【关键词】胃肿瘤;替吉奥;顺铂;药物疗法【中图分类号】R735.2【文献标识码】A【文章编号】1005—8664(2012)05-0425-03Short··termclinalinvestigationofcombinationchemotherapywithTS-1and~splatinonadvancedgastriccancerSHIShu-zhen,QuFan-fie,YUWei—wei,etal(DepartmentofOncology,theThirdPeo
4、ple’sHospitalofDalian,Dalian116033,China)【Abstract】ObjectiveToevaluatetheefectivenessandsafetyofcombinationchemotherapywithTS一1andcisplatinonadvancedgastriccancer.MethodsWeconductedanon—blinded,randomized,con—trolledtrial,53patientswithadvancedgastriccancerwererandomlyassignedtotwogroups.Th
5、etreatmentgroup(n=27)administeredwithTS一1capsule(dosesbasedonpatientsbodysurfacearea:<1.25m,40mg,bid;1.25~1.50m,50mg,bid;>1.50m,60mg,bid,fromday1to14)pluscisplatin(75mg/mfromday1throughday3)every21days.Thecontrolgroup(n=26)administeredwith5-Fu600mg/(m·d)intravenousdripfromday1today5bymicro—
6、pumpinfusioncontinuouslyandcisplatin20mg/(m·d)intravenousdriponday1today5every28days.Theresponserate,lifequalityandadversereactionwereevaluatedafterevery2cycles.ResultsInthetreatmentgrouptheeffectiverate(59.3%),clinicalbeneficialrate(88.9%)andimprovementoflifequality(44.4%)weresignificantly
7、higherthanthoseofthecontrolgrouprespectly(P<0.05).Thedecreaseoflifequalityweref0undin46.2%ofthecontrolgroupand11.1%ofthetreatmentgroup(P<0.05).Themainadverseeventswerealimentarycanaltoxicity,hematologicsystemandhepatotoxicity.Therewasnosignificantdiferen
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