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时间:2020-04-20
《培美曲塞联合顺铂治疗晚期复治乳腺癌的临床研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、日固⋯.论著培美曲塞联合顺铂治疗晚期复治乳腺癌的临床研究郭本成山东省莱芜市人民医院肿瘤科,山东莱芜271100【摘要】目的探究培美曲塞联厶J顷铂治疗晚期复治乳腺癌的临床效果。方法将该院收治的6O例晚期复治乳腺癌(全部为经蒽环类或紫杉类等药物化疗失败)病患作为研究对象,对他们行培美曲塞联厶JI顷铂治疗,具体而言采用培美曲塞500mg]m2+顺铂75mg/m2,行静脉滴注。治疗以21d为1个周期,至少应行2个周期的治疗。治疗结束2周后对病患进行疗效评定。结果该研究60例病患全部进行了疗效评价,其中有l2例完全缓解,18例部分缓解,l6例稳定,l4例进展。其中总有
2、效为30例(12+18),百分比为50.00%;临床控制则为46例(12+18+16),百分比为76.67%。此外,病患中出现了一些不良反应,比如说疲乏、粒细胞减少、恶心呕吐及皮疹等。结论对于经蒽环类或紫杉类等药物化疗失败而晚期复治乳腺癌病患,采用培美曲塞联合顺铂治疗有着很好的疗效,除了提高病患的生存率,同时也能有效减少不良反应或提高其耐受度。临床上,若病患对多种化疗药物产生了耐药性,那么便可以尝试该研究提到的方法,即培美曲塞联合顺铂治疗,值得临床推广及应用。【关键词】培美曲塞;顺铂;晚期复治乳腺癌;疗效【中图分类号】R737.9【文献标识码】A【文章编号】
3、1674—0742(2013)08(a)一0018—02LinicalStudyofPemetrexedCombinedwithCisplatinintheTreatmentofAdvancedBreastCancerGUOBenchengDepartmentofOncology,LaiwuCityPeopleSHospital,Laiwu,ShandongProvince,271100,China[Abstract]ObjectiveTostudytheclinicalefectofpemetrexedcombinedwithcisplatininthet
4、reatmentofadvancedbreastcan-cer.MethodsThispapertook60casesofadvancedbreastcancerpatients(nilhadbeentreatedbychemotherapyofanthracyclineortaxaneandotherdrugs,buttheeffectwasnotgood.)admittedinourhospitalfromJanuary,2010toMay,2012.Thepatientsweregivenpemetrexedcombinedwithcisplatint
5、reatment,specifically,pemetrexed500mg/m2andcisplatin75rag/m2intra—venously.Thetreatmentshouldbeatleasttwoperiods,eachperiodwas21days.Twoweeksafterthetreatment,theefficacywasevaluated.ResultsThecurativeefectsofallthepatientswereevaluated.Among60patients,12casesachievedcompleteremis—
6、sion,18casesobtainedpartialremission,16caseswerestableand14caseswereprogressive.Thetotalefectivecaseswere30(12+18)withtotaleficacyrate50.00%;theclinicalcontrolcaseswere46(12+18+16)withclinicalcontrolrateofwas76.67%.Inaddition,therearesomeadversereactionsinpatients,suchasfatigue,neu
7、tropenia,nauseaandvomitingandrash.ConclusionPemetrexedandcisplatintreatmenthadgoodcurativeefecttoadvancedbreastcancerpatientswhohadbeentreatedbychemotherapyofanthracyclineortaxaneandotherdrugs。butthetreatmentwasfailed.Itcannotonlyimprove山esurvivalrateofthepatients,butalsoefectively
8、reducetheadversereactionor
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