慢性非细菌性前列腺炎患者前列腺液TNF-α、IL-8的检测及临床意义.doc

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1、慢性非细菌性前列腺炎患者前列腺液TNF-a、IL-8的检测及临床意义［摘要］目的：探讨前列腺按摩液(EPS)屮细胞因了白细胞介素(IL-8)及肿瘤坏死因了-a(TNF-a)在III型前列腺炎［慢性非细菌性前列腺炎/慢性盆底疼痛综合征(CAP/CPPS)］诊断、分型中的意义。方法:EL1SA法检测50例临床诊断为III型前列腺炎患者EPS中IL-8及TNF-a水平。结果：慢性非细菌性前列腺炎EPS中IHA型组TNF-a水平与IHB型组、对照组比较,有显著性差异(P<0.05)；IHB型组TNF-a水平与对照组比较,无显著性差异(P>0.05)oIIIA型组IL-8水平与IDB型

2、组、对照组比较,有非常显著性差异(P<0.01)；IIIB型组与对照组比较,有非常显著性差异(P<0.01)o所有患者EPS中TNF-a水平与WBC计数无明显相关性(r=-0.167,P>0.05),IL-8水平与WBC计数的相关性分析显示呈正相关(r=0.836,PV0.01)。结论：检测III型前列腺炎患者EPS中IL-8及TNF-a水平可能有助于III型前列腺炎的分型诊断，并可作为了解病情和评价治疗效果的一个有价值的指标。［关键词］IL-8；TNF-a;慢性非细菌性前列腺炎［中图分类号］R697+.33［文献标识码］A［文章编号11673-7210(2009)05(b)

3、-022-03DetectionandclinicalsignificaneeofTNF-ciandIL-8inEPSofpatientswithchronicnonbacterialprostatitisHUANGZhihong,YUANShaoying,QINZhan,LIShenguo,ZHANGZhaolei(ZhuhaiHospitalofGuangdongProvincialTCMAffiliatedHospitalofGuangzhouUniversityofChineseMedicine,Zhuhai519015,China)［Abstract］Objecti

4、ve:Toinvestigatethesignificanceofinterleukin-8(IL-8)andtumornecrosisfactor-a(TNF-a)inexpressedprostaticsecretion(EPS)fordiagnosisandclassificationofprostatitisIII［chronicnonbacterialprostatitis/chronicpelvicpainsyndrome(CPPS)］.Methods:IL-8andTNF-(1inEPSof50patientswithprostatitisITTweredete

5、ctedbyELISA・Results:ThelevelofTNF-ainEPSofpatientswithchronicnonbacterialprostatitisgroupIIIAwassignificantlydifferentwithgroupIIIBandthecontrolgroup(P<0・05)・LevelofTNF-ahadnostatisticalsignifiesneebetweengroupIIIBandthecontrolgroup(P>0.05).LevelofTL-8ingroupIIIAhadverysignificantclifferene

6、ecomparedwithgroupIIIBandthecontrolgroup(P<0.01);comparedwiththecontrolgroup,IL-8ingroupITTBhaclaverysignificantdifference(P<0.01).TNF-alevelinEPSofallpatientshadnosignificantcorrelationwithWBCcount(r二-0.167,P>0.05),IL-8levelandWBCcountshowedapositivecorrelationbythecorrelationanalysis(r二0.

7、836,P<0.01).Conclusion:ThedetectionofII厂8andTNF-alevelsinpatientswithprostatitismaycontributetodiagnosisandclassificationofprostatitisITTasthevaluableindicatorstounderstanclthestateofanillnessandevaluatetheeffectoftreatment.［Keywords］IL-8;TNF-a；Chronicno