慢性前列腺炎患者前列腺液il-2、il-10和tnf-α的表达变化及意义

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1、硕士学位论文英文摘要ExpressionOfIL一2、IL-10、TNF—位inExpressedProstaticSecretionOfChronicProstatitisAnditsSignificanceABSTRACTOBJECTIVE：Althoughchronicprostatitisisacommondiseaseinurology,Ourunderstandingoftheetiology,diagnosisandtreatmentofprostatitishasnotadvancedwiththatofotherprostatediseas

2、es．OurstudytrytomeasurethecytokinesIL-2、IL-10andTNF-Q，whichareimportantmediatorofinflammation，inEPSofhealthmen，menwithCBP,menwithmaCPPSandIIIbCPPS，todiscussthepossiblemechanismofprostatitisandunderstandtherolesofcytokinesinthediagnosisandtreatmentsofprostatitis．METHODS：FromSeptembe

3、r2007toFebruary2008，fifty-eightmenseenintheThirdXiangYaHospitalwereenrolledtoparticipateintheresearch．Allthepatientshadbeensufferingfromthechronicprostatitissyndrome．PatientswereclassifiedintothreecategoriesaccordingtotheNIHdiagnosiscriteriaforchronicprostatitis：chronicbacteriapros

4、tatitis(CBP)(n_11)，inflammatoryCPPS(n-26)，noninflammatoryCPPS(n_21)．Andwechose12normalpeopleasacontract．CytokinelevelsweremeasuredinEPSbytwo—antibodyenzyme—linkedimmunosorbentassay．AllthedatawereanalyzedbytheV硕士学位论文英文摘要statisticalpackageSPSSforwindows12．0．RESULTS：Themeanageofcontro

5、lgroup，CBP,IIIaCPPSandIIIbCPPSwas27．4，32．5，29．0and29．7respectively,andtherewerenostatisticallysignificantdifferencesbetweenthem．TheNIH-CPSIscoreof．controlgroup，CBP,maCPPSandIIIbCPPSWas：0，18．3士4．4，17．6+3．4，17．1+3．0，therewerenostatisticallydifferencesamongallCPgroups．TheWBCcountsofco

6、ntrolgroup，CBP,llIaCPPSandmbCPPSWas1．5，31．2，25．1and4．4respectively．TherewerenostatisticallysignificantdifferencesbetweenCBPgroupandIIIaCPPSgroup，andthedifferencebetweencontrolgroupandIllbCPPSisalsoinsignificant．ThelevelofTNF一0【incontrolgroup，CBPgroup，IIIaCPPSandIIIbCPPSgroupWas17．8

7、士9．2pg／ml，91．5士34．8pg／ml，74．9士35．1pg／ml，23．9士12．9pg／ml，groupsforCBPandIliaCPPShavehighermeanlevelsofTNF—athancontrolgroupandmbCPPSgroup，andthedifferencesbetweenthemWasstatisticallysignificant．ThemeanlevelofTNF—GtincontrolgroupandIi-[bCPPSgrouphasnostatisticallysignificantdifference

8、s．ThelevelofIL一10ineachgro