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1、慢性乙型肝炎患者检测乙型肝炎病毒大蛋白的临床意义［摘要］目的：探讨乙型肝炎患者检测乙型肝炎病毒大蛋白(HBV-largeprotein,HBV-LP)的临床意义。方法：选择120例慢性乙型肝炎患者，采用免疫荧光法检测乙型肝炎病毒基因(HBvirus-DNA,HBV-DNA),酶联免疫吸附法检测HBV-LP和乙型肝炎表面抗原(HBVeantigen,HBeAg),比较HBV-DNA、HBV-LPRHBeAg的检岀率，比较HBeAg阴性患者HBV-LP、HBV-DNA血清学检出率，分析HBV-DNA、HBV-LP及HBeAg的
2、相关关系。结果：HBV-LP检出率为87.50%,显著高于HBV-DNA(70.00%)(x2=10.9804,P<0.01)和HBeAg检出率(38.33%)(x2=62.1653,P<0.01)；HBeAg阴性患者HBV-LP阳性检出率为82.43%,显著高于HBV-DNA检出率(44.59%)(x2=22.8589,P<0.01)；相关性检验显示HBV-LP与HBV-DNA及HBeAg之间存在正相关关系(rs=0.573,P［关键词］乙型肝炎病毒；大蛋白；临床价值［中图分类号］R446.62［文献标识码］B［文章编号
3、］1673-7210(2011)12(a)-099-02ClinicalsignificaneeofdetectingHBV-LPonpatientswithchronicitytypeBhepatitisZHAOXiaDepartmentofClinicalLaboratory,RedCrossHospitalinNanjingCity,JiangsuProvinee,Nanjing210001,China[Abstract]Objective:Toinvestigatetheclinicalsignificaneeof
4、detectingHBV-largeprotein(HBV・LP)onpatientswithchronicitytypeBhepatitis.Methods:120casesofpatientswithchronicitytypeBhepatitiswereselected,HBV-DNAweredetectedbyimmunofluorescence,HBV-LPandHBVeantigen(HBeAg)weredetectedbyenzymelinkedimmunosorbentassay,thedetectionr
5、ateofHBV-DNA,HBV-LPandHBeAgwerecompared,thedetectionrateofHBV-LPandHBV-DNAwerecomparedinpatientswithnegativeHBeAg,correlationofHBV-LPwithHBeAgandHBV-DNAwasanalyzed.Results:ThedetectionrateofHBV-LP(87.50%)washigherthanHBV-DNA(70.00%)(x2=10.9804,P<0.01)andHbeAg(38.3
6、3%)(x2=62.1653,P<0.01),thedetectionrateofHBV-LP(82.43%)washigherthanthatofHBV-DNA(44.59%)inpatientswithnegativeHBeAg(x2=22.8589,P<0.01),correlationtestingshowntherewerepositivecorrelationbetweenHBV-LPwithHBV-DNAandHBeAg(rs=0.573,P2.2HBeAg阴性患者中HBV-LP与HBV-DNA检测结果74例
7、HBeAg阴性的慢性乙型肝炎患者中，HBV-LP阳性率为82.43%(61/74),HBV-DNA阳性率为44.59%(33/74),HBV-LP阳性率显著高于HBV-DNA阳性率(P
