窒息新生儿血清磷酸肌酸激酶同工酶与肌钙蛋白I的变化及其临床意义.doc

《窒息新生儿血清磷酸肌酸激酶同工酶与肌钙蛋白I的变化及其临床意义.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、窒息新生儿血清磷酸肌酸激酶同工酶与肌钙蛋白I的变化及其临床意义［摘要］目的探讨窒息新生儿血清磷酸肌酸激酶同工酶（CK-MB）与肌钙蛋白I（cTnl）的变化及其临床意义。方法选取本院2011年1月〜2013年11月的117例窒息新生儿作为观察组，其中轻度窒息组70例，重度窒息组47例。选取同期出生的128例无窒息新生儿作为对照组，比较3组的CK-MB及cTnl水平。结果轻度窒息组和重度窒息组的CK-MB、cTnl水平显著高于对照组，差异有统计学意义（P<0.05）o重度窒息组的CK-MB.cTnl水平显著高于轻度窒息组，差异有统计学意义（P〈0・0

2、5）。4d窒息新生儿的CK-MB、cTnl水平显著低于1、2、3d窒息新生儿，差异有统计学意义（卩<0.05）。3d窒息新生儿的CK-MB、cTnl水平显著低于1、2d窒息新生儿,差异有统计学意义（P〈0.05）。2d窒息新生儿的CK-MB、cTnl水平显著低于1d窒息新生儿，差异有统计学意义（卩〈0.05）。结论窒息新生儿的缺氧程度同心肌损害程度成正比，血清CK-MB及cTnl水平可以作为窒息新生儿心肌损害的诊断指标。［关键词］窒息新生儿；血清磷酸肌酸激酶同工酶；肌钙蛋白I［中图分类号］R722.12［文献标识码］A［文章编号］1674-472

3、1（2015）07（c）-0016-03ChangeandclinicalsignificaneeofserumcreatinephosphatekinaseandtroponinTinasphyxia!newbornsZHANGGuo-yingDepartmentofPediatrics,People'sHospitalofBaoanDistrictinShenzhenCity,Shenzhen518101,China[Abstract]ObjectiveToexplorethechangesandclinicalsignificanceofs

4、erumcreatinephosphatekinase(CK-MB)andtroponinI(cTnl)inasphyxialnewborns.Methods117asphyxialneonatesfromJanuary2011toNovember2013inourhospitalwereselectedastheobservationgroup.Amongthem,70caseswereinmildasphyxiaand47caseswereinsevereasphyxia.128neonateswithoutasphyxiainthesame

5、periodwereselectedasthecontrolgroup.ThelevelofCK~MBandcTnlamongthreegroupswascompared.ResultsThe1evelofCK-MBandcTnTinthesevereasphyxiagroupandmildasphyxiagroupwashigherthanthatinthecontrolgrouprespectively,withsignificantdifferenee(卩〈0.05).ThelevelofCK-MBandcTnlinthesevereasp

6、hyxiagroupwashigherthanthatinthemildasphyxiagroup,withsignificantdifference(P<0.05)•ThelevelofCK-MBandcTnTinfour-day-oldchildrenpatientswas1owerthanthatinone,twoandthree-day-oldchildren,withsignificantdifference(P<0.05)・ThelevelofCK-MBandcTnTinthree-day-oldchildrenpatientswas

7、lowerthanthatinoneandtwo-day-oldchildren,withsignificantdifference(P<0.05)・ThelevelofCK-MBandcTnTintwo~day-oldchiIdrenpatientswas1owerthanthatinone-day-oldchildren,withsignificantdifference（P〈0.05）•ConclusionThedegreeofhypoxiainasphyxialnewbornshasapositivecorrelationwiththes

8、everityofmyocardialdamage.The1evelofserumCK-MBandcTnTcanbeconsidered